Chapter 7. Gastric H+,K+-ATPase

  1. Masamitsu Futai2,
  2. Yoh Wada3 and
  3. Jack H. Kaplan4
  1. Jai Moo Shin,
  2. Olga Vagin,
  3. Keith Munson and
  4. George Sachs

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch7

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

How to Cite

Shin, J. M., Vagin, O., Munson, K. and Sachs, G. (2005) Gastric H+,K+-ATPase, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch7

Editor Information

  1. 2

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 3

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 4

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. Membrane Biology Laboratory, West Los Angeles VA Medical Center, 11301 Wilshire Blvd., Los Angeles, CA 90073, USA

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

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Keywords:

  • ATPases;
  • P-type ATPases;
  • gastric H+,K+-ATPase;
  • α subunit of gastric H+,K+-ATPase;
  • β subunit of gastric H+,K+-ATPase;
  • kinetics of H+,K+-ATPase;
  • conformations of the H+,K+-ATPase;
  • functional residues of the H+,K+-ATPase;
  • structural model of the H+,K+-ATPase;
  • acid secretion and H+,K+-ATPase;
  • inhibitors of the H+,K+-ATPase

Summary

This chapter contains sections titled:

  • Gastric H+,K+-ATPase

    • α Subunit of Gastric H+,K+-ATPase

    • β Subunit of Gastric H+,K+-ATPase

    • Regions of Association Between the α and β Subunits

    • Regions of Association of the α Subunits

  • Kinetics of the H+,K+-ATPase

  • Conformations of the H+,K+-ATPase

  • Functional Residues of the H+,K+-ATPase

  • Structural Model of the H+,K+-ATPase

    • Crystal Structure of the H+,K+-ATPase

    • Molecular Modeling of the Gastric H+,K+-ATPase

  • Acid Secretion and the H+,K+-ATPase

  • Inhibitors of the H+,K+-ATPase

    • Substituted Benzimidazoles

    • Substituted Imidazo[1,2α]pyridines and other K+-competitive Antagonists

  • Trafficking of the H+,K+-ATPase

  • References