Chapter 9. Proton Translocating ATPases: Introducing Unique Enzymes Coupling Catalysis and Proton Translocation through Mechanical Rotation

  1. Masamitsu Futai1,
  2. Yoh Wada2 and
  3. Jack H. Kaplan3
  1. Masamitsu Futai1,
  2. Ge-Hong Sun-Wada1 and
  3. Yoh Wada2

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch9

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

How to Cite

Futai, M., Sun-Wada, G.-H. and Wada, Y. (2004) Proton Translocating ATPases: Introducing Unique Enzymes Coupling Catalysis and Proton Translocation through Mechanical Rotation, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch9

Editor Information

  1. 1

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 2

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 3

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. 1

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 2

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

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Keywords:

  • ATPases;
  • F-type ATPases;
  • proton translocating ATPases;
  • unique enzymes;
  • coupling catalysis and proton translocation;
  • mechanical rotation;
  • catalytic mechanism of F-ATPase;
  • roles of the γ subunit;
  • rotational catalysis;
  • F-ATPase holoenzyme;
  • rotational catalysis of V-ATPase

Summary

This chapter contains sections titled:

  • Abbreviations

  • Introduction

  • Catalytic Mechanism of F-ATPase

  • Roles of the γ subunit: energy coupling by mechanical rotation

    • Roles of the γ Subunit in Energy Coupling

    • γ Subunit Rotation

    • Mutational Analysis of the γ Subunit Rotation

  • Rotational Catalysis of the F-ATPase Holoenzyme

    • Structure of Fo Sector and Proton Transport Pathway

    • Rotational Catalysis of the F-ATPase Holoenzyme

    • Rotational Catalysis of F-ATPase in Membranes

  • Rotational catalysis of V-ATPase

    • Catalytic Site and Proton Pathway

    • Subunit Rotation of V-ATPase During Catalysis

  • Epilogue

  • Acknowledgments

  • References