III. Contributions — C: Carcinogenic Factors: Endogenous

  1. Deutsche Forschungsgemeinschaft (DFG) and
  2. Senate Commission on Food Safety (SKLM)
  1. Steven R. Tannenbaum1,
  2. Bernd Epe2,
  3. D. Ballmaier,
  4. O. Will,
  5. S. Hollenbach,
  6. H.-C. Mahler,
  7. M. I. Homburg,
  8. J. P. Radicella and
  9. Prof. Dr. Wolfgang Scheppach3

Published Online: 5 JAN 2006

DOI: 10.1002/3527606246.ch3c

Carcinogenic and Anticarcinogenic Factors in Food: Symposium

Carcinogenic and Anticarcinogenic Factors in Food: Symposium

How to Cite

Tannenbaum, S. R., Epe, B., Ballmaier, D., Will, O., Hollenbach, S., Mahler, H.-C., Homburg, M. I., Radicella, J. P. and Scheppach, W. (2000) Contributions — C: Carcinogenic Factors: Endogenous, in Carcinogenic and Anticarcinogenic Factors in Food: Symposium (eds Deutsche Forschungsgemeinschaft (DFG) and Senate Commission on Food Safety (SKLM)), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606246.ch3c

Author Information

  1. 1

    Massachusetts Institute of Technology, Department of Chemistry and Whitaker College (Room 56–311), Cambridge, MA 02139-4307, USA; Tel.: 0016172533729; FAX: 0016172588676

  2. 2

    Universität Mainz, Institut für Pharmazie, Abt. für Pharmakologie und Toxikologie, Staudinger Weg 5, D-55099 Mainz, Germany; Tel.: 00496131394309; FAX: 00496131395521

  3. 3

    Klinikum der bayrischen Julius-Maximilians-Universität Würzburg, Luitpoldkrankenhaus, Josef Schneider Straße 2, D-97080 Würzburg, Germany; Tel.: 00499312013183; FAX: 00499312013534

Publication History

  1. Published Online: 5 JAN 2006
  2. Published Print: 17 JUL 2000

ISBN Information

Print ISBN: 9783527271443

Online ISBN: 9783527606245

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Keywords:

  • carcinogenic factors;
  • anticarcinogenic factors;
  • foods;
  • endogenous;
  • DNA damage;
  • nitrogen;
  • oxygen free radicals;
  • modulation by dietary constituents;
  • colonic SCFA concentrations;
  • butyrate;
  • effect on histones

Summary

This chapter contains sections titled:

  • DNA Damage by Nitrogen and Oxygen Free Radicals and its Modulation by Dietary Constituents

    • Abstract

    • Chemistry of nitric oxide

    • Nitric oxide-induced DNA damage via the N2O3 pathway

    • DNA damage from peroxynitrite

    • NO-induced mutagenesis

  • Oxidative DNA Damage and its Cellular Consequences

    • Abstract

    • Introduction

    • Steady-state levels of oxidative DNA modifications in mammalian cells

    • Factors that influence the steady-state levels of oxidative DNA damage

    • Mutagenicity associated with oxidative DNA damage

    • Conclusions

  • Fermentation Profiles in the Gut and Functional Effects of Food Components

    • Abstract

    • Introduction

    • Colonic SCFA concentrations and carcinogenesis

    • SCFAs and proliferation of normal colonocytes

    • Butyrate and colonic “hyperproliferation”

    • Butyrate and adenoma cell lines

    • Butyrate, propionate, and proliferation of colon cancer cell lines

    • Butyrate and markers of differentiation

    • Effect of butyrate on histones

    • Effects of butyrate on gene expression

    • Butyrate and tumor invasiveness

    • Butyrate as a treatment for metastatic cancer in experimental animals

    • Conclusion