III. Contributions — D: Anticarcinogenic Factors

  1. Deutsche Forschungsgemeinschaft (DFG) and
  2. Senate Commission on Food Safety (SKLM)
  1. Dr. Anthony T. Diplock1,
  2. Frau Prof. Dr. Beatrix L. Pool-Zobel2,
  3. Prof. Dr. Gerhard Rechkemmer3,
  4. Dr. Stephen S. Hecht4,
  5. Dr. Chung S. Yang5,
  6. Guang-Yu Yang,
  7. Sungbin Kim,
  8. Mao-Jung Lee,
  9. Jie Liao,
  10. Jee Chung,
  11. Dr. Lilian U. Thompson6,
  12. Dr. Takuji Tanaka7,
  13. Prof. Dr. Henk J. van Kranen8 and
  14. C. F. van Kreijl

Published Online: 5 JAN 2006

DOI: 10.1002/3527606246.ch3d

Carcinogenic and Anticarcinogenic Factors in Food: Symposium

Carcinogenic and Anticarcinogenic Factors in Food: Symposium

How to Cite

Diplock, A. T., Pool-Zobel, B. L., Rechkemmer, G., Hecht, S. S., Yang, C. S., Yang, G.-Y., Kim, S., Lee, M.-J., Liao, J., Chung, J., Thompson, L. U., Tanaka, T., van Kranen, H. J. and van Kreijl, C. F. (2006) Contributions — D: Anticarcinogenic Factors, in Carcinogenic and Anticarcinogenic Factors in Food: Symposium (eds Deutsche Forschungsgemeinschaft (DFG) and Senate Commission on Food Safety (SKLM)), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606246.ch3d

Author Information

  1. 1

    University of London, United Medical and Dental School, Guys' Hospital, Guys' Campus: London Bridge, London SE1 9RT, Great Britain, UK; Tel.: 00441719554621; FAX: 00441714037195

  2. 2

    Institut für Ernährung und Umwelt, Friedrich Schiller Universität, Dornburgerstr. 25, D-07743 Jena, Germany; Tel.: 00493641949671; FAX: 00493641949672

  3. 3

    Federal Research Center for Nutrition, Institute of Nutritional Physiology, D-76344 Eggenstein-Leopoldshafen, Germany; Tel.: 00497247823600; FAX: 0049724722820

  4. 4

    University of Minnesota Cancer Center, Box 806 – UMHC, 420 Delaware St., S.E. Minneapolis, MN 55455-0392, USA; Tel.: 0016126247604; FAX: 0016126265135

  5. 5

    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08854-8020, USA; Tel.: 0019084455360; FAX: 0017324450687

  6. 6

    Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, 150 College Street, Toronto, Ontario, M5S 3E2, Canada; Tel.: 0014169783523; FAX: 0014169785882

  7. 7

    Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan; Tel.: 0081 762862211 (3613); FAX: 0081 762866926

  8. 8

    Department of Carcinogenesis, Mutagenesis and Genetics, Laboratory of Health Effects Research, National Institute of Public Health and the Environment, Bilthoven, The Netherlands; Tel.: 0031 302742182; FAX: 0031 302744446

Publication History

  1. Published Online: 5 JAN 2006
  2. Published Print: 17 JUL 2000

ISBN Information

Print ISBN: 9783527271443

Online ISBN: 9783527606245

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Keywords:

  • carcinogenic factors;
  • anticarcinogenic factors;
  • foods;
  • free radicals;
  • modulation by antioxidants;
  • lipid peroxidation and carcinogenesis;
  • anticarcinogenic factors in plant foods;
  • concept of chemoprevention/dietary prevention;
  • anthocyans;
  • anticarcinogenic activity of carotenoids;
  • anticarcinogenesis by isothiocyanates;
  • indole-3-carbinol;
  • allium thiols;
  • tea and cancer;
  • epidemiological studies;
  • lignans and isoflavones;
  • non-nutritive compounds in foods;
  • chemopreventive agents

Summary

This chapter contains sections titled:

  • Involvement of Free Radicals in Carcinogenesis and Modulation by Antioxidants

    • Abstract

    • Introduction

    • Free radical generation and DNA as target for attack

    • Lipid peroxidation and carcinogenesis

    • Modulation by dietary antioxidants of free radical attack: epidemiological studies

    • Enhancement of antioxidant intake and safety

  • Anticarcinogenic Factors in Plant Foods and Novel Techniques to Elucidate Their Potential Chemopreventive Activities

    • Abstract

    • Introduction

    • Mechanisms of carcinogenesis

    • The concept of chemoprevention/dietary prevention

    • Phytoprotectants

    • Mechanisms of protective activities

      • Antigenotoxic activities

      • Antioxidative activities

      • Induction of chemopreventive enzymes

      • Antiproliferative activity

      • Induction of apoptosis

      • Modulation of biomarkers

    • Conclusions

  • Carotenoids and Anthocyans

    • Abstract

    • Introduction

    • Carotenoids

      • Evidence for anticarcinogenic activity of carotenoids

    • β-Carotene

      • ATBC

      • CARET

      • Conclusions from ATBC and CARET

    • Lycopene

    • Other carotenoids

    • Anthocyanins

      • Experimental evidence for anticarcinogenic activity of anthocyanins

  • Anticarcinogenesis by Isothiocyanates, Indole-3-carbinol, and Allium Thiols

    • Abstract

    • Isothiocyanates and glucosinolates

      • Occurrence and formation

      • Inhibition of carcinogenesis by isothiocyanates, glucosinolates, and cruciferous vegetables

      • Mechanisms of chemoprevention by isothiocyanates

    • Indole-3-carbinol

      • Occurrence and formation

      • Effects of indole-3-carbinol on carcinogenesis

      • Mechanisms of chemoprevention by indole-3-carbinol

    • Thiols of Allium plants

      • Occurrence and formation

      • Effects of Allium thiols on carcinogenesis

      • Mechanisms of chemoprevention by Allium thiols

    • Conclusions

  • Tea and Cancer: What Do We Know and What Do We Need to Know?

    • Abstract

    • Introduction

    • Studies with animal models

      • Inhibition of lung tumorigenesis

      • Inhibition of skin tumorigenesis

      • Studies on colon and breast cancers

    • Epidemiological studies

    • Possible active components and their bioavailability

      • Possible active components

      • Absorption and tissue distribution in animals

      • Blood and saliva levels in humans

    • Possible mechanisms for the inhibitory actions of tea on tumorigenesis

    • Concluding remarks

  • Lignans and Isoflavones

    • Abstract

    • Introduction

    • Anticancer effects

      • Epidemiological studies

      • In vitro studies

      • Animal studies

        • Soybean and isoflavones

      • Breast cancer

      • Other cancers

        • Flaxseed and lignans

          • Breast cancer

          • Other cancers

      • Clinical studies

    • Safety

    • Conclusion and future research

  • Chemoprevention of Colon Carcinogenesis by Non-Nutritive Compounds in Foods

    • Abstract

    • Introduction

    • Screening of possible chemopreventive agents against rat colon tumorigenesis ability using a 5-week short-term bioassay of ACF

    • Evaluation of chemopreventive ability of selected compounds using a long-term rat colon carcinogenesis model

    • Chemoprevention of rat colon carcinogenesis by DIO and HPD

    • Chemoprevention of rat colon carcinogenesis by ACA

    • Chemoprevention of rat colon carcinogenesis by AUR

    • Discussion

  • Chemoprevention of Intestinal Neoplasia

    • Abstract

    • Manuscript