Chapter 2.2. Solventless Reactions (SLR)

  1. Professor Dr. Carlos A. M. Afonso2 and
  2. Professor Dr. João G. Crespo3
  1. Rajender S. Varma and
  2. Yuhong Ju

Published Online: 9 FEB 2006

DOI: 10.1002/3527606602.ch2b

Green Separation Processes: Fundamentals and Applications

Green Separation Processes: Fundamentals and Applications

How to Cite

Varma, R. S. and Ju, Y. (2005) Solventless Reactions (SLR), in Green Separation Processes: Fundamentals and Applications (eds C. A. M. Afonso and J. G. Crespo), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606602.ch2b

Editor Information

  1. 2

    CQFM, Department of Chemical Engineering, Instituto Superior Técnico, 1049-001 Lisbon, Portugal

  2. 3

    REQUIMTE/CQFB, Department of Chemistry, FCT/Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal

Author Information

  1. Sustainable Technology Devision, National Risk Management Research Laboratory, US Environmental Protection Agency, 26 West Martin Luther King Drive, MS443, Cincinnnati, Ohio, 45268, USA

Publication History

  1. Published Online: 9 FEB 2006
  2. Published Print: 25 MAY 2005

ISBN Information

Print ISBN: 9783527309856

Online ISBN: 9783527606603



  • solventless reactions (SLR);
  • solventless (neat) reactions;
  • solventless microwave-assisted reactions;
  • microwave-assisted solventless reactions on solid supports;
  • reduction reactions;
  • condensation reactions


This chapter contains sections titled:

  • Introduction

  • Solventless (Neat) Reactions (by Mixing or Grinding)

    • Solvent-free Robinson Annulation

    • Chemoselective, Solvent-free aldol Condensation Reactions

    • Knoevenagel Condensation Free of Solvent and Catalyst

    • Solventless Oxidation Using the Urea–Hydrogen Peroxide Complex (UHP)

    • Expeditious Synthesis of 1-Aryl-4-methyl-1,2,4-triazolo[4,3-a]-quinoxalines

    • Solventless Wittig Olefination

  • Solventless Microwave-assisted Reactions

    • Microwave-assisted Solventless Synthesis of Heterocycles

    • Microwave-assisted Solventless Condensations

    • Microwave-assisted Solventless Oxidation

    • Amination of Aryl Halides without a Transition Metal Catalyst

    • Microwave-accelerated Transformation of Carbonyl Functions to their Thio Analogues

  • Microwave-assisted Solventless Reactions on Solid Supports

    • Protection–Deprotection (Cleavage) Reactions

    • Condensation Reactions

    • Solventless Rearrangement Promoted by MW Irradiation

    • Oxidation Reactions – Oxidation of Alcohols and Sulfides

    • Reduction Reactions

    • Microwave-assisted Synthesis of Heterocyclic Compounds on Solid Supports

  • Miscellaneous Reactions

    • Solvent-free Preparation of Ionic Liquids Using Microwaves

    • Enzyme-catalyzed Reactions

  • Conclusion