Chapter 3. Evolution of Synthetic Polymers with Enzyme-like Catalytic Activities

  1. Prof. Dr. Ronald Breslow
  1. Irving M. Klotz1 and
  2. Junghun Suh2

Published Online: 24 MAR 2006

DOI: 10.1002/3527606645.ch3

Artificial Enzymes

Artificial Enzymes

How to Cite

Klotz, I. M. and Suh, J. (2005) Evolution of Synthetic Polymers with Enzyme-like Catalytic Activities, in Artificial Enzymes (ed R. Breslow), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606645.ch3

Editor Information

  1. Columbia University, Department of Chemistry, 556 Chandler Laboratory, New York, NY 10027-6948, USA

Author Information

  1. 1

    Northwestern University, Department of Chemistry, 2145 Sheridan Road, Evanston, IL 60208-3113, USA

  2. 2

    Seoul National University, Department of Chemistry, Seoul 151-747, Korea

Publication History

  1. Published Online: 24 MAR 2006
  2. Published Print: 25 MAY 2005

ISBN Information

Print ISBN: 9783527311651

Online ISBN: 9783527606641



  • artificial enzymes;
  • evolution of synthetic polymers with enzyme-like catalytic activities;
  • conceptual background;
  • homogeneous polymer biocatalysts;
  • heterogeneous polymer biocatalysts;
  • prospectives


This chapter contains sections titled:

  • Introduction: Conceptual Background

  • Homogeneous Polymer Biocatalysts

    • Fabrication of Macromolecules with Strong Affinities for Ligands

    • Enhanced Reactivity of Nucleophiles in Polyethylenimines (PEIs)

    • Polyethylenimines with Nucleophile Adducts

    • Proximal Group Adducts to Polyethylenimines

    • Polyethylenimines (PEIs) with Adducts that Self-assemble into Catalytic Moieties

  • Heterogeneous Polymer Biocatalysts

    • Random Catalytic Adducts

    • Proximal Group Adducts

    • Adducts Containing Catalytic Modules Synthesized Prior to Incorporation into Polymers

    • Adducts giving Nuclease Activity to Polymers

  • Prospectives