Chapter 10. Cell Fusion in Development and Disease

  1. Prof. Dr. Lukas K. Tamm
  1. Prof. Benjamin Podbilewicz1,
  2. Dr. Leonid V. Chernomordik2

Published Online: 29 MAR 2006

DOI: 10.1002/3527606769.ch10

Book Title

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Additional Information

How to Cite

Podbilewicz, B. and Chernomordik, L. V. (2006) Cell Fusion in Development and Disease, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch10

Editor Information

  1. Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Author Information

  1. 1

    Department of Biology, Technion Israel Institute of Technology, Technion City, Haifa 32000, Israel

  2. 2

    Laboratory of Cellular and Molecular Biophysics, Section on Membrane Biology, National Institute of Child Health and Human Development, National Institutes of Health, 10 Center Drive, Building 10, Bethesda, MD 20892-1855, USA

Publication History

  1. Published Online: 29 MAR 2006
  2. Published Print: 5 AUG 2005

ISBN Information

Print ISBN: 9783527311514

Online ISBN: 9783527606764

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Keywords:

  • cell fusion in development and disease;
  • development cell fusion for health;
  • eff-1;
  • cell fusion mediated by enveloped viruses

Summary

This chapter contains sections titled:

  • Introduction

  • Developmental Cell Fusion for Health

    • Muscles

      • Vertebrates

      • Drosophila

    • C. elegans

      • Epithelial Cell Fusion Assay in C. elegans

      • Control of Cell Fusion

      • Developmental Genetics of Cell Fusion in C. elegans

      • eff-1 Mutant Epidermal Cells do not Initiate Cell Membrane Fusion

      • eff-1-mediated Cell Fusion is Essential for Healthy Organogenesis

      • eff-1 Encodes Novel Type I Membrane and Secreted Proteins

      • eff-1 is Highly Expressed in Epidermal Cells Ready to Fuse

      • eff-1 is Sufficient for Cell Membrane Fusion in vivo

      • Tissue-specific Fusogenic Activity of eff-1 in Pharyngeal Muscles

    • Comparison between Cell Fusion in a Worm, a Fly and Vertebrates

  • Cell Fusion in Diseases

    • Cell Fusion Mediated by Enveloped Viruses

      • Dissection of Viral Membrane Fusion

      • Initiation and Expansion of Membrane Fusion

      • Protein–Protein and Protein–Lipid Interactions in Membrane Fusion

      • The Role of Fusion Proteins Outside the Fusion Site

      • HA Insiders Initiate Hemifusion and HA Outsiders Expand Fusion Pores

      • Models for Final Expansion of Fusion Pores

  • Dissection of Developmental Fusion Based on Viral Fusion Analogies

    • Activation of a Developmental Fusogen

    • Dissection of Developmental Cell Fusion

    • Direct Cell Fusion Promotion or Indirect Relaxation of Fusion Blocks

  • Concluding Remarks

  • References

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