Chapter 11. Molecular Mechanisms of Intracellular Membrane Fusion

  1. Prof. Dr. Lukas K. Tamm
  1. Dr. Olga Vites,
  2. Prof. Reinhard Jahn

Published Online: 29 MAR 2006

DOI: 10.1002/3527606769.ch11

Book Title

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Additional Information

How to Cite

Vites, O. and Jahn, R. (2006) Molecular Mechanisms of Intracellular Membrane Fusion, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch11

Editor Information

  1. Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Author Information

  1. Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany

Publication History

  1. Published Online: 29 MAR 2006
  2. Published Print: 5 AUG 2005

ISBN Information

Print ISBN: 9783527311514

Online ISBN: 9783527606764

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Keywords:

  • molecular mechanisms of intracellular membrane fusion;
  • intracellular fusion reactions;
  • tethering and docking;
  • SNARE proteins;
  • fusion catalysts;
  • SM proteins;
  • fusion pores

Summary

This chapter contains sections titled:

  • Introduction

  • Intracellular Fusion Reactions – An Overview

  • Tethering and Docking

  • SNARE Proteins – The Fusion Catalysts?

    • Assembly–Disassembly Cycle of SNARE Proteins

    • N-terminal Domains of SNAREs – Recruiting Proteins or Regulating SNARE Function?

    • “Zippering” Model for SNARE-mediated Membrane Fusion

    • Trans-complexes – Intermediates in the Fusion Pathway?

    • Acceptor Complexes, Topology and Specificity

      • SNARE Acceptor Complexes

      • Topology of SNAREs

      • Specificity of SNAREs

    • Challenges of the SNARE Hypothesis

      • Persistence of Fusion in Spite of SNARE Deletions

      • Late-acting Factors Uncovered in Yeast Vacuolar Fusion

      • Exocytosis of Cortical Granules in Sea Urchin Oocytes

  • SM Proteins and Other Regulators

    • SM Proteins

  • Fusion Pores

    • Measuring Fusion Pore Opening and Closure

    • The Role of Proteins in Controlling Fusion Pore Opening

  • Concluding Remarks

  • List of Abbreviations

  • References

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