Chapter 12. Interplay of Proteins and Lipids in Virus Entry by Membrane Fusion

  1. Prof. Dr. Lukas K. Tamm
  1. Alex L. Lai1,
  2. Dr. Yinling Li1,
  3. Prof. Dr. Lukas K. Tamm2

Published Online: 29 MAR 2006

DOI: 10.1002/3527606769.ch12

Book Title

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Additional Information

How to Cite

Lai, A. L., Li, Y. and Tamm, L. K. (2006) Interplay of Proteins and Lipids in Virus Entry by Membrane Fusion, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch12

Editor Information

  1. Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Author Information

  1. 1

    Department of Molecular Physiology and Biological Physics, University of Virginia, 1300 Jefferson Park Avenue, P.O. Box 800 736, Charlottesville, VA 22908-0736, USA

  2. 2

    Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Publication History

  1. Published Online: 29 MAR 2006
  2. Published Print: 5 AUG 2005

ISBN Information

Print ISBN: 9783527311514

Online ISBN: 9783527606764

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CHAPTER TOOLS

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Keywords:

  • interplay of proteins and lipids in virus entry by membrane fusion;
  • fusion of pure lipid bilayers;
  • viral protein sequences that mediate lipid bilayer fusion;
  • interactions of fusion peptides with lipid bilayers;
  • interactions of transmembrane domains with lipid bilayers

Summary

This chapter contains sections titled:

  • Introduction

  • Fusion of Pure Lipid Bilayers

  • Viral Protein Sequences that Mediate Lipid Bilayer Fusion

    • Fusion Peptides

    • Transmembrane Domains

    • Other Regions of the Fusion Protein

  • Interactions of Fusion Peptides with Lipid Bilayers

    • HIV Fusion Peptide–Bilayer Interactions

    • Influenza Fusion Peptide Structure

    • Influenza Fusion Peptide Mutants

    • Binding of Fusion Peptides to Lipid Bilayers

    • Sendai, Measles and Ebola Fusion Peptide–Bilayer Interactions

    • Perturbation of Bilayer Structure by Fusion Peptides

  • Interactions of Transmembrane Domains with Lipid Bilayers

  • Structure–Function (Fusion) Relationships of Membrane-interactive Viral Fusion Protein Domains

    • Fusion Peptide Mutants

    • Transmembrane Domain Mutants

  • Possible Mechanisms for Initiating the Formation of Viral Fusion Pores

  • References

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