Chapter 17. Structural Mechanisms of Allosteric Regulation by Membrane-binding Domains

  1. Prof. Dr. Lukas K. Tamm
  1. Dr. Bertram Canagarajah1,
  2. Dr. William J. Smith2,
  3. Dr. James H. Hurley1

Published Online: 29 MAR 2006

DOI: 10.1002/3527606769.ch17

Book Title

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Additional Information

How to Cite

Canagarajah, B., Smith, W. J. and Hurley, J. H. (2006) Structural Mechanisms of Allosteric Regulation by Membrane-binding Domains, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch17

Editor Information

  1. Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Author Information

  1. 1

    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, US Department of Health and Human Services, 50 South Drive, Bethesda, MD 20892, USA

  2. 2

    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, 50 South Drive, Bethesda, MD 20892, USA

Publication History

  1. Published Online: 29 MAR 2006
  2. Published Print: 5 AUG 2005

ISBN Information

Print ISBN: 9783527311514

Online ISBN: 9783527606764

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Keywords:

  • structural mechanisms of allosteric regulation by membrane-binding domains;
  • Rho family-specific guanine nucleotide exchange factors (GEFs);
  • DH and PH domain Rho GEFs;
  • β2-chimaerin

Summary

This chapter contains sections titled:

  • Introduction

  • How Membranes and PH Domains Regulate Rho Family-specific Guanine Nucleotide Exchange Factors (GEFs)

    • DH and PH Domain Rho GEFs

    • Regulation of GEF Activity by PH Domains

  • Regulation of G-protein Receptor Kinase (GRK) 2 Activity by Lipids and the Gβγ Subunit at the Membrane

  • Lipid Activation of Rac-GAP Activity: β2-Chimaerin

    • The C1 Domain of β2-Chimaerin is Buried

    • Mechanism of Allosteric Rac-GTPase Activation by the C1 Domain

  • References

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