Chapter 3. A Paradigm of Membrane Protein Folding: Principles, Kinetics and Stability of Bacteriorhodopsin Folding

  1. Prof. Dr. Lukas K. Tamm
  1. Prof. Paula J. Booth

Published Online: 29 MAR 2006

DOI: 10.1002/3527606769.ch3

Book Title

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Additional Information

How to Cite

Booth, P. J. (2006) A Paradigm of Membrane Protein Folding: Principles, Kinetics and Stability of Bacteriorhodopsin Folding, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch3

Editor Information

  1. Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Author Information

  1. Membrane Protein Folding Group, Department of Biochemistry, University of Bristol, University Walk, Bristol, BS8 1TD, UK

Publication History

  1. Published Online: 29 MAR 2006
  2. Published Print: 5 AUG 2005

ISBN Information

Print ISBN: 9783527311514

Online ISBN: 9783527606764

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CHAPTER TOOLS

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Keywords:

  • membrane protein folding;
  • principles;
  • kinetics;
  • stability of bacteriorhodopsin folding;
  • α-helical membrane protein folding;
  • bacteriorhodopsin folding kinetics;
  • controlling membrane protein folding

Summary

This chapter contains sections titled:

  • Introduction

  • Principles of Transmembrane α-Helical Membrane Protein Folding: A Thermodynamic Model for Bacteriorhodopsin

  • Bacteriorhodopsin Stability

    • Side-chain Contributions to Helix Interactions and the Role of Pro

    • Helix-connecting Loops

  • Pulling the Protein Out of the Membrane

  • Bacteriorhodopsin Folding Kinetics

    • Cotranslational Insertion

    • Retinal Binding Studies to Apomembrane

    • Unfolding, Refolding and Kinetic Studies in vitro

  • Controlling Membrane Protein Folding

  • Conclusions

    • Summary of Bacteriorhodopsin Folding

    • Implications for Transmembrane α-Helical Membrane Protein Folding

  • References

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