Chapter 4. Post-integration Misassembly of Membrane Proteins and Disease

  1. Prof. Dr. Lukas K. Tamm
  1. Prof. Charles R. Sanders

Published Online: 29 MAR 2006

DOI: 10.1002/3527606769.ch4

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

How to Cite

Sanders, C. R. (2006) Post-integration Misassembly of Membrane Proteins and Disease, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch4

Editor Information

  1. Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Author Information

  1. Department of Biochemistry and Center for Structural Biology, Room 5110C, MRBIII, Vanderbilt University, Nashville, TN 37027, USA

Publication History

  1. Published Online: 29 MAR 2006
  2. Published Print: 5 AUG 2005

ISBN Information

Print ISBN: 9783527311514

Online ISBN: 9783527606764

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Keywords:

  • post-integration misassembly of membrane proteins and disease;
  • misassembly-prone membrane proteins;
  • common mutations in transmembrane domains

Summary

This chapter contains sections titled:

  • Introduction

  • A Given IMP May be Subject to Numerous Disease-linked Mutations

  • Ligand Rescue of Misassembly-prone Membrane Proteins: Implications

  • What IMP Properties Affect Folding Efficiency in the Cell?

  • Common Mutations in Transmembrane Domains That Lead to Misassembly and Disease

  • Correlating Biophysical, Cell-biological and Biomedical Measurements

  • References