Chapter 5. A Census of Ordered Lipids and Detergents in X-ray Crystal Structures of Integral Membrane Proteins
- Prof. Dr. Lukas K. Tamm
Published Online: 29 MAR 2006
DOI: 10.1002/3527606769.ch5
Copyright © 2005 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Protein-Lipid Interactions: From Membrane Domains to Cellular Networks
Additional Information
How to Cite
Wiener, M. C. (2006) A Census of Ordered Lipids and Detergents in X-ray Crystal Structures of Integral Membrane Proteins, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch5
Editor Information
Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA
Publication History
- Published Online: 29 MAR 2006
- Published Print: 5 AUG 2005
ISBN Information
Print ISBN: 9783527311514
Online ISBN: 9783527606764
- Summary
- Chapter
Keywords:
- ordered lipids and detergents in X-ray crystal structures of integral membrane proteins;
- lipids;
- detergents;
- structures of lipids in membrane protein co-crystals;
- protein–protein interfaces;
- protein–lipid interfaces
Summary
This chapter contains sections titled:
Introduction
Results
Illustrative Examples of Selected Bound Lipids, Detergents and Related Molecules
Integral Membrane Protein Structures Contain Ordered Native Lipids
Structures of Lipids in Membrane Protein Co-crystals Differ from Those in Pure Lipid Crystals
Native Lipids can Stabilize and Preserve Protein–Protein Interfaces
Multiple Acyl Chain Conformations Exist for Efficient Packing with Protein Interfaces
Lipid Acyl Chains Interact Primarily with Aliphatic and Aromatic Amino Acid Side-chains
Unusual Lipid/Detergent Conformations Occur at the Protein–Lipid Interface
A Bilayer Structure is Present in Crystals Grown from the LCP
Conclusion
References