Chapter 6. Lipid and Detergent Interactions with Membrane Proteins Derived from Solution Nuclear Magnetic Resonance

  1. Prof. Dr. Lukas K. Tamm
  1. Dr. Ashish Arora

Published Online: 29 MAR 2006

DOI: 10.1002/3527606769.ch6

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

How to Cite

Arora, A. (2006) Lipid and Detergent Interactions with Membrane Proteins Derived from Solution Nuclear Magnetic Resonance, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch6

Editor Information

  1. Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Author Information

  1. Department of Molecular and Structural Biology, Central Drug Research Institute, Chattar Manzil Palace, P.O. Box 173, M.G. Marg, Lucknow 226001, UP, India

Publication History

  1. Published Online: 29 MAR 2006
  2. Published Print: 5 AUG 2005

ISBN Information

Print ISBN: 9783527311514

Online ISBN: 9783527606764

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Keywords:

  • lipid and detergent interactions with membrane proteins;
  • heteronuclear solution NMR of protein/detergent complexes;
  • choice of detergents;
  • size and shape of pure detergent micelles and detergent/protein complexes

Summary

This chapter contains sections titled:

  • Introduction

  • Heteronuclear Solution NMR of Protein/Detergent Complexes

  • Choice of Detergents

  • Size and Shape of Pure Detergent Micelles and Detergent/Protein Complexes

  • Sample Preparation for Solution NMR Measurements

  • Protein/Detergent Interactions Monitored by NMR Spectroscopy

  • Dynamics and Conformational Transitions of Membrane Proteins in Detergent Micelles

  • MD Simulations of Protein/Detergent Complexes

  • Implications on the Structure and Function of Membrane Proteins in Biological Membranes

  • References