Chapter 8. Membrane Recognition and Pore Formation by Bacterial Pore-forming Toxins

  1. Prof. Dr. Lukas K. Tamm
  1. Dr. Alejandro P. Heuck1,
  2. Prof. Arthur E. Johnson2

Published Online: 29 MAR 2006

DOI: 10.1002/3527606769.ch8

Book Title

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Protein-Lipid Interactions: From Membrane Domains to Cellular Networks

Additional Information

How to Cite

Heuck, A. P. and Johnson, A. E. (2006) Membrane Recognition and Pore Formation by Bacterial Pore-forming Toxins, in Protein-Lipid Interactions: From Membrane Domains to Cellular Networks (ed L. K. Tamm), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606769.ch8

Editor Information

  1. Professor of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908-0736, USA

Author Information

  1. 1

    Department of Medical Biochemistry and Genetics, Texas A&M University System, Health Science Center, 116 Reynolds Medical Building, College Station, TX 77843-1114, USA

  2. 2

    College of Medicine, Texas A&M University System, Health Science Center, 116 Reynolds Medical Building, College Station, TX 77843-1114, USA

Publication History

  1. Published Online: 29 MAR 2006
  2. Published Print: 5 AUG 2005

ISBN Information

Print ISBN: 9783527311514

Online ISBN: 9783527606764

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CHAPTER TOOLS

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Keywords:

  • membrane recognition and pore formation by bacterial pore-forming toxins;
  • classification of bacterial PFTs;
  • oligomerization on the membrane surface;
  • membrane penetration;
  • pore formation

Summary

This chapter contains sections titled:

  • Introduction

  • Classification of Bacterial PFTs

    • α-PFTs

    • β-PFTs

  • A General Mechanism of Pore Formation?

  • Membrane Recognition

    • Recognition of Specific Membrane Lipids

    • Recognition of Membrane-anchored Proteins or Carbohydrates

    • The Role of Membrane Lipid Domains

  • Oligomerization on the Membrane Surface

    • Oligomerization Triggered by Lipid-induced Conformational Changes

    • Oligomerization Following Proteolytic Activation of Toxins

  • Membrane Penetration and Pore Formation

  • Unresolved Issues

  • References

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