Chapter 10. Macrophages – Balancing Tolerance and Immunity

  1. PD Dr. Harald Kropshofer2 and
  2. Dr. Anne B. Vogt3
  1. Nicholas S. Stoy

Published Online: 10 APR 2006

DOI: 10.1002/3527607021.ch10

Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

How to Cite

Stoy, N. S. (2005) Macrophages – Balancing Tolerance and Immunity, in Antigen Presenting Cells: From Mechanisms to Drug Development (eds H. Kropshofer and A. B. Vogt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607021.ch10

Editor Information

  1. 2

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 3

    Roche Centre for Medical Genomics, Building 86/804, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Author Information

  1. Royal Hospital for Neurodisability, Huntington's Disease Unit, West Hill, Putney, London, SW15 3SW, UK

Publication History

  1. Published Online: 10 APR 2006
  2. Published Print: 25 AUG 2005

ISBN Information

Print ISBN: 9783527311088

Online ISBN: 9783527607020

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Keywords:

  • antigen presenting cells;
  • repertoire of antigen presenting cells;
  • macrophages;
  • balancing tolerance and immunity;
  • asthma;
  • autoimmunity;
  • immune system modeling;
  • therapeutics

Summary

This chapter contains sections titled:

  • Balancing Tolerance and Immunity

    • Introduction

    • Macrophage Phenotypes: Effects on Immunity and Tolerance

    • Concept of Innate (Peripheral) Tolerance

    • Concept of Adaptive Tolerance

    • Innate Tolerance: Receptors, Responses and Mechanisms

    • Incorporating NK and NT Cells into the Innate Tolerance/Innate Immunity Paradigm

    • Definitions and Terminology

  • Ramifications of the Paradigm: Asthma

  • Ramifications of the Paradigm: Autoimmunity

  • Summary and Conclusions: Towards Immune System Modeling and Therapeutics