Chapter 13. Contribution of B Cells to Autoimmune Pathogenesis

  1. PD Dr. Harald Kropshofer3 and
  2. Dr. Anne B. Vogt4
  1. Thomas Dörner1 and
  2. Peter E. Lipsky2

Published Online: 10 APR 2006

DOI: 10.1002/3527607021.ch13

Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

How to Cite

Dörner, T. and Lipsky, P. E. (2005) Contribution of B Cells to Autoimmune Pathogenesis, in Antigen Presenting Cells: From Mechanisms to Drug Development (eds H. Kropshofer and A. B. Vogt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607021.ch13

Editor Information

  1. 3

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 4

    Roche Centre for Medical Genomics, Building 86/804, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Author Information

  1. 1

    University Medicine Berlin, Campus Mitte, Coagulation Unit, Schumannstr. 20/21, 10098 Berlin, Germany

  2. 2

    National Institutes of Health, NIAMS, Autoimmunity Branch, 9000 Rockville Pike, Bethesda, MD 20892-1560, USA

Publication History

  1. Published Online: 10 APR 2006
  2. Published Print: 25 AUG 2005

ISBN Information

Print ISBN: 9783527311088

Online ISBN: 9783527607020

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Keywords:

  • antigen presenting cells;
  • repertoire of antigen presenting cells;
  • B cells and autoimmune pathogenesis;
  • autoimmunity and immune deficiency;
  • diversity to B cell receptor;
  • disturbed homeostasis of peripheral B cells;
  • signal transduction pathways in B cells;
  • B cell abnormalities;
  • rheumatoid arthritis;
  • depleting anti-B cell therapy;
  • novel therapeutic strategy

Summary

This chapter contains sections titled:

  • Introduction

  • Autoimmunity and Immune Deficiency

    • Basic Mechanisms Providing Diversity to the B Cell Receptor

    • Ig V Gene Usage by B Cells of Healthy Individuals

    • Potential Abnormalities in Molecular Mechanisms Underlying IgV Gene Usage in Systemic Autoimmune Diseases

    • Lack of Molecular Differences in V(D)J Recombination in Patients with Systemic Autoimmune Diseases

    • Receptor Editing/Revision and Autoimmunity

    • Selective Influences Shaping the Ig V Gene Repertoire in Autoimmune Diseases

      • IgV Gene Usage by Autoantibodies

    • Role of Somatic Hypermutation in Generating Autoantibodies

  • Disturbed Homeostasis of Peripheral B Cells in Autoimmune Diseases

  • Signal Transduction Pathways in B Cells

    • B Cell Function Results from Balanced Agonistic and Antagonistic Signals

      • Altered B Cell Longevity can Lead to Autoimmunity

      • Altered B Cell Activation can Lead to Autoimmunity

      • Inhibitory Receptors of B Cells

      • Inhibitory Receptor Pathways and Autoimmunity

  • B Cell Abnormalities Leading to Rheumatoid Arthritis

    • Activated B Cells may Bridge the Innate and Adaptive Immune System

    • “Humoral Imprinting” in Rheumatoid Arthritis

    • Indications of Enhanced B Cell Activity in RA

    • T Cell Independent B Cell Activation

  • Depleting anti-B Cell Therapy as a Novel Therapeutic Strategy