Chapter 16. Antigen Presenting Cells as Drug Targets

  1. PD Dr. Harald Kropshofer2 and
  2. Dr. Anne B. Vogt3
  1. Siquan Sun,
  2. Robin L. Thurmond and
  3. Lars Karlsson

Published Online: 10 APR 2006

DOI: 10.1002/3527607021.ch16

Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

How to Cite

Sun, S., Thurmond, R. L. and Karlsson, L. (2005) Antigen Presenting Cells as Drug Targets, in Antigen Presenting Cells: From Mechanisms to Drug Development (eds H. Kropshofer and A. B. Vogt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607021.ch16

Editor Information

  1. 2

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 3

    Roche Centre for Medical Genomics, Building 86/804, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Author Information

  1. Johnson & Johnson Pharmaceutical, Department of Immunology Research and Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA

Publication History

  1. Published Online: 10 APR 2006
  2. Published Print: 25 AUG 2005

ISBN Information

Print ISBN: 9783527311088

Online ISBN: 9783527607020

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Keywords:

  • antigen presenting cells;
  • antigen presenting cell-based drug development;
  • antigen presenting cells as drug targets;
  • roles of DC in disease;
  • marketed drugs affecting APC function;
  • DC-based immunotherapy therapy

Summary

This chapter contains sections titled:

  • Introduction

  • Roles of DC in disease

    • Transplantation

    • Autoimmune Diseases

    • Allergy/Asthma

    • Cancer

  • Marketed Drugs Affecting APC function

  • New Potential APC Drug Targets

    • APC Activation

    • Antigen Presentation

    • Co-stimulation

    • Cell Adhesion

    • APC Chemotaxis

    • APC Survival

    • Intracellular Signaling

    • APC Depletion

  • APC per se as Drugs – DC-based Immunotherapy Therapy

    • DC-based Cancer Vaccines

    • Targeting and Activating DC In Vivo

    • DC-based Immunotherapy for Transplantation and Autoimmune Diseases

  • Conclusion