Chapter 5. Antigen Processing and Presentation by CD1 Family Proteins

  1. PD Dr. Harald Kropshofer3 and
  2. Dr. Anne B. Vogt4
  1. Steven A. Porcelli1 and
  2. D. Branch Moody2

Published Online: 10 APR 2006

DOI: 10.1002/3527607021.ch5

Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

How to Cite

Porcelli, S. A. and Moody, D. B. (2006) Antigen Processing and Presentation by CD1 Family Proteins, in Antigen Presenting Cells: From Mechanisms to Drug Development (eds H. Kropshofer and A. B. Vogt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607021.ch5

Editor Information

  1. 3

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 4

    Roche Centre for Medical Genomics, Building 86/804, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Author Information

  1. 1

    Albert Einstein College of Medicine, Department of Microbiology and Immunology and Department of Medicine, Room 416 Forchheimer Building, 1300 Morris Park Avenue, Bronx, NY 10461, USA

  2. 2

    Brigham and Women's Hospital, Division of Rheumatology, Immunology & Allergy, Room 514 Smith Building, 1 Jimmy Fund Way, Boston, MA 02115, USA

Publication History

  1. Published Online: 10 APR 2006
  2. Published Print: 25 AUG 2005

ISBN Information

Print ISBN: 9783527311088

Online ISBN: 9783527607020

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Keywords:

  • antigen presenting cells;
  • molecular mechanisms;
  • antigen processing;
  • CD1 family proteins;
  • CD1 genes;
  • classification of CD1 proteins;
  • structure;
  • biosynthesis;
  • foreign lipid antigens presented;
  • group 1 CD1;
  • self lipid antigens;
  • group 2 CD1-restricted T cells;
  • subcellular distribution;
  • intracellular trafficking of CD1;
  • CD1 pathway

Summary

This chapter contains sections titled:

  • Introduction

  • CD1 Genes and Classification of CD1 Proteins

  • Structure and Biosynthesis of CD1 Proteins

    • Three-dimensional (3D) Structures of CD1 Proteins

    • Molecular Features of CD1–Lipid Complexes

    • CD1 Pockets and Portals

  • Foreign Lipid Antigens Presented by Group 1 CD1

  • Self Lipid Antigens Presented by CD1

  • Group 2 CD1-restricted TCells

    • Antigens Recognized by Group 2 CD1-restricted TCells

  • Tissue Distribution of CD1 Proteins

  • Subcellular Distribution and Intracellular Trafficking of CD1

    • Trafficking and Localization of CD1a

    • Trafficking and Localization of CD1b

    • Trafficking and Localization of CD1c

    • Trafficking and Localization of CD1d

    • Trafficking and Localization of CD1e

  • Antigen Uptake, Processing and Loading in the CD1 Pathway

    • Cellular Uptake of CD1-presented Antigens

    • Endosomal Processing of CD1-presented Antigens

    • Accessory Molecules for Endosomal Lipid Loading of CD1

    • Non-endosomal Loading of Lipids onto CD1 Molecules

  • Conclusions