Chapter 6. Naturally Processed Self-peptides of MHC Molecules

  1. PD Dr. Harald Kropshofer2 and
  2. Dr. Anne B. Vogt3
  1. PD Dr. Harald Kropshofer2 and
  2. Sebastian Spindeldreher1

Published Online: 10 APR 2006

DOI: 10.1002/3527607021.ch6

Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

How to Cite

Kropshofer, H. and Spindeldreher, S. (2005) Naturally Processed Self-peptides of MHC Molecules, in Antigen Presenting Cells: From Mechanisms to Drug Development (eds H. Kropshofer and A. B. Vogt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607021.ch6

Editor Information

  1. 2

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 3

    Roche Centre for Medical Genomics, Building 86/804, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Author Information

  1. 1

    F. Hoffmann La Roche AG, Roche Center for Medical Genomics, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 2

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Publication History

  1. Published Online: 10 APR 2006
  2. Published Print: 25 AUG 2005

ISBN Information

Print ISBN: 9783527311088

Online ISBN: 9783527607020

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Keywords:

  • antigen presenting cells;
  • ligands recognized by T-and Toll-like receptors;
  • naturally processed self-peptides of MHC molecules;
  • sequence analysis of natural peptides;
  • natural class II MHC-associated peptides;
  • different tissues and cell-types;
  • natural peptides;
  • diagnostic or therapeutic tools

Summary

This chapter contains sections titled:

  • Introduction

  • Milestone Events

    • Nomenclature

      • Autologous Peptides

      • Endogenous Peptides

      • Natural Peptides Ex Vivo and In Vitro

    • Extra Electron Density Associated to MHC Molecules

    • Acidic Peptide Elution Approach

    • First Natural Foreign Peptides on MHC Class II

    • First Natural Viral Epitopes on MHC Class I

    • Self-peptide Sequencing on MHC Class I: the First Anchor Motifs

    • First Murine MHC Class II-associated Self-peptides: Nested Sets

    • First Human MHC Class II-bound Self-peptides: Hydrophobic Motifs

  • Progress in Sequence Analysis of Natural Peptides

    • Edman Microsequencing

    • Electrospray Ionization Tandem Mass Spectrometry

    • Automated Tandem Mass Spectrometry

    • MAPPs: MHC-associated Peptide Proteomics

  • Natural Class II MHC-associated Peptides from Different Tissues and Cell-types

    • Peripheral Blood Mononuclear Cells

    • Myeloid Dendritic Cells

    • Medullary Thymic Epithelial Cells

    • Splenic APCs

    • Tumor Cells

    • Autoimmunity-related Epithelial Cells

  • The CLIP Story

    • CLIP in APCs Lacking HLA-DM

    • Flanking Residues and Self-release of CLIP

    • CLIP in Tetraspan Microdomains

    • CLIP as an Antagonist of TH1 Cells

  • Outlook: Natural Peptides as Diagnostic or Therapeutic Tools