Chapter 7. Target Cell Contributions to Cytotoxic T Cell Sensitivity

  1. PD Dr. Harald Kropshofer3 and
  2. Dr. Anne B. Vogt4
  1. Tatiana Lebedeva1,
  2. Michael L. Dustin2 and
  3. Yuri Sykulev1

Published Online: 10 APR 2006

DOI: 10.1002/3527607021.ch7

Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

How to Cite

Lebedeva, T., Dustin, M. L. and Sykulev, Y. (2005) Target Cell Contributions to Cytotoxic T Cell Sensitivity, in Antigen Presenting Cells: From Mechanisms to Drug Development (eds H. Kropshofer and A. B. Vogt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607021.ch7

Editor Information

  1. 3

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 4

    Roche Centre for Medical Genomics, Building 86/804, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Author Information

  1. 1

    Department of Microbiology and Immunology and Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA

  2. 2

    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 504 First Avenue, New York, NY 10016, USA

Publication History

  1. Published Online: 10 APR 2006
  2. Published Print: 25 AUG 2005

ISBN Information

Print ISBN: 9783527311088

Online ISBN: 9783527607020

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Keywords:

  • antigen presenting cells;
  • ligands recognized by T-and Toll-like receptors;
  • target cell;
  • cytotoxic T cell sensitivity;
  • intercellular adhesion molecule 1 (ICAM-1);
  • Major Histocompatability Complex (MHC)

Summary

This chapter contains sections titled:

  • Introduction

  • Intercellular Adhesion Molecule 1 (ICAM-1)

    • Adhesion Molecules on the Surface of APC and Target Cells

    • ICAM-1 Structure and Topology on the Cell Surface

    • ICAM-1 as Co-stimulatory Ligand and Receptor

    • ICAM-1-mediated Signaling

    • Role of ICAM-1 in Endothelial Response to Leukocytes

    • ICAM-1 Association with Lipid Rafts

  • Major Histocompatability Complex (MHC)

    • MHC Molecules

    • Molecular Associations of MHC-I Molecules

    • Association of MHC-I and ICAM-1

    • Could APC and Target Cells Play an Active Role in Ag Presentation?

    • Identical pMHCs are Clustered in the Same Microdomain

    • Identical pMHC can be Recruited to the Same Microdomain During Target Cell-T Cell Interaction

    • Co-clustering of MHC and Accessory Molecules

    • Role of Cytoskeleton

  • Conclusion