Chapter 8. Stimulation of Antigen Presenting Cells: from Classical Adjuvants to Toll-like Receptor (TLR) Ligands

  1. PD Dr. Harald Kropshofer3 and
  2. Dr. Anne B. Vogt4
  1. Martin F. Bachmann1 and
  2. Annette Oxenius2

Published Online: 10 APR 2006

DOI: 10.1002/3527607021.ch8

Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

How to Cite

Bachmann, M. F. and Oxenius, A. (2005) Stimulation of Antigen Presenting Cells: from Classical Adjuvants to Toll-like Receptor (TLR) Ligands, in Antigen Presenting Cells: From Mechanisms to Drug Development (eds H. Kropshofer and A. B. Vogt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607021.ch8

Editor Information

  1. 3

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 4

    Roche Centre for Medical Genomics, Building 86/804, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Author Information

  1. 1

    Cytos Biotechnology AG, Wagistr. 25, 8952 Zürich-Schlieren, Switzerland

  2. 2

    Swiss Federal Institute of Technology, Institute for Microbiology, Wolfgang-Pauli-Str., 8093 Zürich, Switzerland

Publication History

  1. Published Online: 10 APR 2006
  2. Published Print: 25 AUG 2005

ISBN Information

Print ISBN: 9783527311088

Online ISBN: 9783527607020

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Keywords:

  • antigen presenting cells;
  • ligands recognized by T-and toll-like receptors (TLR);
  • stimulation of antigen presenting cells;
  • synopsis;
  • pathogen-associated features;
  • efficient immune responses;
  • composition of adjuvants;
  • function of adjuvants;
  • TLR protein family in mammals;
  • TLR signaling;
  • therapeutic potential of TLRs/ligands

Summary

This chapter contains sections titled:

  • Synopsis

  • Pathogen-associated Features that Drive Efficient Immune Responses

  • Composition and Function of Adjuvants

  • TLR Protein Family in Mammals

    • TLR4

    • TLR2

    • TLR5

    • TLR11

    • TLR12 and TLR13

    • Nucleic Acids as PAMPs

      • TLR3

      • TLR7 and TLR8

      • TLR9

    • Compartmentalization of Sensing Renders the Nucleic Acid PAMPs

  • TLR Signaling

    • Signal Transduction Across the Membrane

    • MyD88-dependent Pathways

    • MyD88-independent Pathways

  • TLR-independent Recognition of PAMPs: Nods, PKR and Dectin-1

    • Nods

    • PKR (IFN-inducible dsRNA-dependent Protein Kinase)

    • Dectin-1

  • Therapeutic Potential of TLRs and their Ligands

  • Conclusion