Chapter 9. Evolution and Diversity of Macrophages

  1. PD Dr. Harald Kropshofer2 and
  2. Dr. Anne B. Vogt3
  1. Nicholas S. Stoy

Published Online: 10 APR 2006

DOI: 10.1002/3527607021.ch9

Antigen Presenting Cells: From Mechanisms to Drug Development

Antigen Presenting Cells: From Mechanisms to Drug Development

How to Cite

Stoy, N. S. (2005) Evolution and Diversity of Macrophages, in Antigen Presenting Cells: From Mechanisms to Drug Development (eds H. Kropshofer and A. B. Vogt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607021.ch9

Editor Information

  1. 2

    Roche Centre for Medical Genomics, Building 86/805, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

  2. 3

    Roche Centre for Medical Genomics, Building 86/804, F. Hoffmann-La Roche AG, Grenzacherstr. 124, 4070 Basel, Switzerland

Author Information

  1. Royal Hospital for Neurodisability, Huntington's Disease Unit, West Hill, Putney, London, SW15 3SW, UK

Publication History

  1. Published Online: 10 APR 2006
  2. Published Print: 25 AUG 2005

ISBN Information

Print ISBN: 9783527311088

Online ISBN: 9783527607020

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Keywords:

  • antigen presenting cells;
  • repertoire of antigen presenting cells;
  • evolution of macrophages;
  • diversity of macrophages;
  • mammalian tissues;
  • immunity without antigen presentation

Summary

This chapter contains sections titled:

  • Evolution of Macrophages: Immunity without Antigen Presentation

    • Introduction

    • Drosophila: a Window into Innate Immunity

    • Evolution of Adaptive Immunity: Macrophages in a New Context

  • Diversity of Macrophages in Mammalian Tissues

    • Classifying Heterogeneity

    • Phenotypic Manipulations and Transdifferentiations: Routes to and from Macrophages

    • Function-related ‘Markers’ in Macrophages and DCs

    • Macrophage Phenotypic Diversity in Response to Microbial Challenge

    • Interactions between Tissue Microenvironments and Macrophages Generate Diversity

    • Sequential and Regulatory Changes in Macrophage Phenotypes: Limiting Pro- and Antiinflammatory Responses

      • Pre-TLR and TLR Regulation of Immune Responses

      • Signal Transduction in the Regulation of Immune Responses

      • Regulation of Immune Responses by Cytokines and other Bioactive Molecules

      • Regulation of Immune Responses by Decoys

      • Regulation of Immune Responses by the Adaptive Immune System

      • Regulation of Immune Responses by Apoptosis

      • Interaction of Regulatory Mechanisms during Immune Responses

    • Macrophage Diversity: an Overview