Chapter 15. Virally Encoded Constitutively Active Chemokine Receptors

  1. Prof. Roland Seifert2 and
  2. Prof. Thomas Wieland3
  1. Barbara Moepps and
  2. Peter Gierschik

Published Online: 25 APR 2006

DOI: 10.1002/352760734X.ch15

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, Volume 24

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, Volume 24

How to Cite

Moepps, B. and Gierschik, P. (2005) Virally Encoded Constitutively Active Chemokine Receptors, in G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, Volume 24 (eds R. Seifert and T. Wieland), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760734X.ch15

Editor Information

  1. 2

    Department of Pharmacology and Toxicology, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany

  2. 3

    Institut für Pharmakologie und Toxikologie, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Maybachstraße 14-16, 68169 Mannheim, Germany

Author Information

  1. Abteilung Pharmakologie und Toxikologie, Universität Ulm, Albert-Einstein-Allee 11, 89081 Ulm, Germany

Publication History

  1. Published Online: 25 APR 2006
  2. Published Print: 26 SEP 2005

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold4,
  2. Prof. Dr. Hugo Kubinyi5 and
  3. Prof. Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Biomedical Research Center, Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zentrum, 8092 Zürich, Switzerland

ISBN Information

Print ISBN: 9783527308194

Online ISBN: 9783527607341

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Keywords:

  • G protein coupled receptors (GPCR);
  • virally encoded constitutively active chemokine receptors;
  • human cytomegalovirus-encoded chemokine receptor homologue pUS28;
  • human Kaposi's Sarcoma virus-encoded chemokine receptor KSHV-GPCR;
  • characteristics of infection;
  • functional characteristics;
  • signalling pathways;
  • regulation of transcriptional activity;
  • structure–function relationships;
  • cellular functions of KHSV-GPCR

Summary

This chapter contains sections titled:

  • Introduction

    • Viral Strategies to Evade the Host Immune System

    • Chemokines and Chemokine Receptors

    • Viral Homologues of Chemokines and Chemokine Receptors and Viral Chemokine-binding Proteins

  • The Human Cytomegalovirus-encoded Chemokine Receptor Homologue pUS28

    • Characteristics of Human Cytomegalovirus Infection

    • Functional Characteristics of pUS28

    • Signaling Pathways Regulated by pUS28

    • Regulation of Transcriptional Activity by pUS28

    • Regulation of Constitutively Active pUS28

    • Cellular Functions of pUS28

  • The Human Kaposi's Sarcoma Virus-encoded Chemokine Receptor KSHV-GPCR

    • Characteristics of Human Kaposi's Sarcoma Virus Infection

    • Functional Characteristics of KSHV-GPCR

    • Signaling Pathways Regulated by KSHV-GPCR

    • Regulation of Transcriptional Activity by KHSV-GPCR

    • Regulation of KSHV Activity by Chemokines

    • Structure–Function Relationships of KHSV-GPCR

    • Cellular Functions of KHSV-GPCR in vivo

  • Conclusions