Chapter 5. Naturally Occurring Constitutively Active Receptors: Physiological and Pharmacological Implications

  1. Prof. Roland Seifert2 and
  2. Prof. Thomas Wieland3
  1. Alan S. Kopin and
  2. Martin Beinborn

Published Online: 25 APR 2006

DOI: 10.1002/352760734X.ch5

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, Volume 24

G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, Volume 24

How to Cite

Kopin, A. S. and Beinborn, M. (2005) Naturally Occurring Constitutively Active Receptors: Physiological and Pharmacological Implications, in G Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity, Volume 24 (eds R. Seifert and T. Wieland), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760734X.ch5

Editor Information

  1. 2

    Department of Pharmacology and Toxicology, University of Regensburg, Universitätsstraße 31, D-93053 Regensburg, Germany

  2. 3

    Institut für Pharmakologie und Toxikologie, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Maybachstraße 14-16, 68169 Mannheim, Germany

Author Information

  1. Molecular Pharmacology Research Center, Molecular Cardiology Research Institute, Tufts-New England Medical Center, Box 7703, 750 Washington Street, Boston, MA 02111, USA

Publication History

  1. Published Online: 25 APR 2006
  2. Published Print: 26 SEP 2005

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold4,
  2. Prof. Dr. Hugo Kubinyi5 and
  3. Prof. Dr. Gerd Folkers6

Series Editor Information

  1. 4

    Biomedical Research Center, Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 5

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 6

    Collegium Helveticum, STW/ETH Zentrum, 8092 Zürich, Switzerland

ISBN Information

Print ISBN: 9783527308194

Online ISBN: 9783527607341

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Keywords:

  • G protein coupled receptors (GPCR);
  • constitutively active receptors;
  • physiological implications;
  • pharmacological implications;
  • wild-type receptor subtypes;
  • wild-type alternatively spliced receptors;
  • polymorphisms in GPCRs;
  • GPCR mutation-induced disease

Summary

This chapter contains sections titled:

  • Introduction

  • Wild-type Interspecies Homologues

  • Wild-type Receptor Subtypes within a Given Species

  • Wild-type Alternatively Spliced Receptors

  • Polymorphisms in GPCRs

  • GPCR Mutation-induced Disease

  • Future Challenges