Chapter 15. Autoantibodies in Diabetes

  1. Prof. Dr. K. Michael Pollard
  1. Sarah M. Weenink,
  2. Michael R. Christie

Published Online: 31 MAY 2006

DOI: 10.1002/3527607854.ch15

Book Title

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Additional Information

How to Cite

Weenink, S. M. and Christie, M. R. (2006) Autoantibodies in Diabetes, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch15

Editor Information

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Author Information

  1. Beta Cell Development and Function Group, Division of Reproductive Health, Endocrinology and Development, 2nd Floor Hodgkin Building, King's College London, Guy's Campus, London SE1 1UL, United Kingdom

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 25 NOV 2005

ISBN Information

Print ISBN: 9783527311415

Online ISBN: 9783527607853

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CHAPTER TOOLS

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Keywords:

  • autoimmunity;
  • antibodies in diabetes;
  • Islet-cell antigens;
  • insulin as an autoantigen;
  • Islet autoantibodies

Summary

This chapter contains sections titled:

  • Introduction

  • Islet-cell Antigens

    • Insulin as an Autoantigen

    • Glutamic Acid Decarboxylase

    • IA-2 (ICA512) and Phogrin (IA-2)

    • Other Target Antigens

  • Islet Autoantibodies and the Prediction of Type 1 Diabetes

    • Antibody Detection and Standardization

    • Development of Islet Autoantibodies in Early Life

    • Distribution of Antibodies in Diabetic Patients at Time of Disease Diagnosis

    • Islet Autoantibodies and Diabetes Prediction

  • Relationship of Islet Autoantibodies to T-cell Responses in Type 1 Diabetes

  • Conclusions

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