Chapter 17. Autoantibody Recognition of Macromolecular Structures and Their Subunits

  1. Prof. Dr. K. Michael Pollard
  1. Erica A. Champion1,
  2. Susan J. Baserga2

Published Online: 31 MAY 2006

DOI: 10.1002/3527607854.ch17

Book Title

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Additional Information

How to Cite

Champion, E. A. and Baserga, S. J. (2006) Autoantibody Recognition of Macromolecular Structures and Their Subunits, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch17

Editor Information

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Author Information

  1. 1

    Department of Genetics, Yale University, 333 Cedar Street, New Haven, CT 06520-8024, USA

  2. 2

    Department of Molecular Biophysics and Biochemistry, Department of Genetics, and Department of Therapeutic Radiology, Yale University, 333 Cedar Street, P.O. Box 208024, New Haven, CT 06520-8024, USA

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 25 NOV 2005

ISBN Information

Print ISBN: 9783527311415

Online ISBN: 9783527607853

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Keywords:

  • autoantibody recognition of macromolecular structures;
  • mechanism of Pre-mRNA splicing;
  • U3 and the box C/D small nucleolar RNAs (snoRNAs);
  • La and Ro autoantigens;
  • RNase P and RNase MRP;
  • exosome;
  • NOR-90/hUBF and RNA polymerases I, II, and III

Summary

This chapter contains sections titled:

  • Autoantibodies Used to Probe the Function of Macromolecular Structures

  • Autoantibodies as Probes for the Mechanism of Pre-mRNA Splicing

    • Patients with Systemic Lupus Erythematosus (SLE) Make Antibodies to snRNPs

    • Are snRNPs Involved in Splicing?

    • A Useful Tool: Anti-Sm Monoclonal Antibodies Derived from an SLE Mouse Model

    • Autoantibodies Are Used to Test Whether snRNPs Are Involved in Pre-mRNA Splicing

    • The Protein Components of snRNPs

    • Subcellular Localization of Splicing Components

    • Specific Autoantibodies to Each Spliceosomal snRNP

    • SLE Led the Way to Our Current Understanding of the Mechanism of Pre-mRNA Splicing

  • U3 and the Box C/D Small Nucleolar RNAs (snoRNAs)

    • The U3 snoRNA in Ribosome Biogenesis

    • Fibrillarin Is the First U3-associated Protein

    • Fibrillarin Autoantibodies Uncover a New Class of snoRNAs

  • The La and Ro Autoantigens

    • Ro and La Are Related Autoantigens

    • The La snRNPs

    • The Ro scRNPs

  • RNase P and RNase MRP

    • RNase P and RNase MRP Are Structurally Related

    • A New Function of RNase MRP

    • The Structure and Architecture of RNase P and RNase MRP

    • Current and Future Uses for Autoantibodies in the Study of RNase P and RNase MRP

  • The Exosome

    • A Molecular Marker for Polymyositis-Scleroderma Overlap Syndrome

    • The Exosome Is a Conserved Complex

    • Autoantibody Targets in the Human Exosome

  • NOR-90/hUBF and RNA Polymerases I, II, and III

    • RNA Polymerases I, II, and III

    • The Nucleolar-organizing Region

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