Chapter 19. Tolerance and Immunity to the Ro/La RNP Complex†

  1. Prof. Dr. K. Michael Pollard
  1. Catherine L. Keech1,
  2. Tom P. Gordon2,
  3. James McCluskey1

Published Online: 31 MAY 2006

DOI: 10.1002/3527607854.ch19

Book Title

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Additional Information

How to Cite

Keech, C. L., Gordon, T. P. and McCluskey, J. (2006) Tolerance and Immunity to the Ro/La RNP Complex, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch19

Editor Information

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Author Information

  1. 1

    Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria 3010, Australia

  2. 2

    Department of Immunology, Arthritis, and Allergy, Flinders University of South Australia, Bedford Park, South Australia 5042, Australia

  1. †

    A list of abbreviations used is located at the end of this chapter.

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 25 NOV 2005

ISBN Information

Print ISBN: 9783527311415

Online ISBN: 9783527607853

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Keywords:

  • tolerance and immunity to the Ro/La RNP complex;
  • autoimmune response to La;
  • Ro/La ribonucleoprotein complex;
  • autoimmune findings in humans;
  • tolerance to nuclear antigens;
  • tolerance in the T-cell compartment;
  • induction of disease

Summary

This chapter contains sections titled:

  • Introduction

  • The Nature of the Autoimmune Response to La

  • The Ro/La Ribonucleoprotein Complex

  • Autoimmune Findings in Humans

  • Autoimmunity to La in Experimental Models

  • Tolerance to Nuclear Antigens

  • Lack of Tolerance in the B-cell Compartment

  • Tolerance in the T-cell Compartment

  • Induction of Disease

  • Anti-La Autoantibodies Are Pathogenic in the Neonatal Lupus Syndrome

  • Concluding Remarks

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