Chapter 20. Autoantibody Recognition of Functional Sites

  1. Prof. Dr. K. Michael Pollard
  1. Carlo Selmi1,
  2. Sabine Oertelt1,
  3. Pietro Invernizzi2,
  4. Mauro Podda2,
  5. M. Eric Gershwin1

Published Online: 31 MAY 2006

DOI: 10.1002/3527607854.ch20

Book Title

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Additional Information

How to Cite

Selmi, C., Oertelt, S., Invernizzi, P., Podda, M. and Gershwin, M. E. (2006) Autoantibody Recognition of Functional Sites, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch20

Editor Information

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Author Information

  1. 1

    Division of Rheumatology, Allergy, and Clinical Immunology, University of California at Davis, Davis, CA 95616, USA

  2. 2

    Division of Internal Medicine, San Paolo School of Medicine, University of Milan, Via di Rudini 8, 20142 Milan, Italy

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 25 NOV 2005

ISBN Information

Print ISBN: 9783527311415

Online ISBN: 9783527607853

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CHAPTER TOOLS

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Keywords:

  • autoantibody recognition of functional sites;
  • anti-mitochondrial antibodies (AMAs) in primary biliary cirrhosis;
  • enzyme inhibition;
  • xenobiotics and AMA

Summary

This chapter contains sections titled:

  • Introduction

  • Anti-mitochondrial Antibodies in Primary Biliary Cirrhosis

    • Biochemistry of the 2-Oxoacid Dehydrogenase Complex

    • Epitopes in Biliary Epithelia

  • Enzyme Inhibition

  • Xenobiotics and AMA

  • Microorganisms and AMAs

  • AMAs in the Pathogenesis of PBC

  • Other Autoantibodies in PBC

  • Concluding Remarks and Future Directions

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