Chapter 24. Genetic Manipulation
- Prof. Dr. K. Michael Pollard
Published Online: 31 MAY 2006
DOI: 10.1002/3527607854.ch24
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease
Additional Information
How to Cite
Pickering, M. C. and Botto, M. (2006) Genetic Manipulation, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch24
Editor Information
Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Publication History
- Published Online: 31 MAY 2006
- Published Print: 25 NOV 2005
ISBN Information
Print ISBN: 9783527311415
Online ISBN: 9783527607853
- Summary
- Chapter
Keywords:
- genetic manipulation;
- genetic pathways leading to autoimmunity;
- genetically manipulated models
Summary
This chapter contains sections titled:
Introduction
Genetic Pathways Leading to Autoimmunity: Lessons from Genetically Manipulated Models
Dysregulation of the Immune Response
Perturbations in Lymphocyte Homeostasis7
Defects in the Scavenging Mechanisms
Introduction
Mechanisms of Apoptotic Cell Clearance
Apoptotic Cells: A Potential Source of Lupus Autoantigens
Complement Deficiency and SLE
Complement Promotes the Clearance of Dying Cells in vitro and in vivo
Clearance of Apoptotic Cells: Tolerance versus Autoimmunity
Epistatic Effects of Background Genes on Gene-targeted Models of SLE: The Importance of Appropriate Controls
Conclusions