Chapter 3. Self/Non-self Recognition

  1. Prof. Dr. K. Michael Pollard
  1. Alan G. Baxter

Published Online: 31 MAY 2006

DOI: 10.1002/3527607854.ch3

Book Title

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Additional Information

How to Cite

Baxter, A. G. (2006) Self/Non-self Recognition, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch3

Editor Information

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Author Information

  1. Comparative Genomics Centre, Molecular Sciences Building 21, James Cook University, Townsville, QLD 4811, Australia

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 25 NOV 2005

ISBN Information

Print ISBN: 9783527311415

Online ISBN: 9783527607853

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CHAPTER TOOLS

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Keywords:

  • autoantibodies;
  • autoimmunity;
  • self/non-self recognition;
  • immunological self;
  • clonal selection theory;
  • self post-burnet

Summary

This chapter contains sections titled:

  • Introduction

  • Immunological Self

    • Burnet's Self-marker Hypothesis

    • A Confusion of Level: Adaptive Enzymes

    • The Boundaries of Self

    • Prenatal Tolerance: Testing the Model

  • The Clonal Selection Theory

    • Immune Theories of Natural Selection

    • Clonal Selection

    • Corollaries of the Clonal Selection Theory

  • Self Post-Burnet

    • The Immunologists' Dirty Little Secret

    • The Missing Self Hypothesis

  • Conclusions

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