Chapter 4. Central and Peripheral Tolerance
- Prof. Dr. K. Michael Pollard
Published Online: 31 MAY 2006
DOI: 10.1002/3527607854.ch4
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease
Additional Information
How to Cite
Rubin, R. L. (2006) Central and Peripheral Tolerance, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch4
Editor Information
Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Publication History
- Published Online: 31 MAY 2006
- Published Print: 25 NOV 2005
ISBN Information
Print ISBN: 9783527311415
Online ISBN: 9783527607853
- Summary
- Chapter
Keywords:
- autoantibodies;
- autoimmunity;
- central and peripheral tolerance;
- ignorance of lymphocytes to target antigen;
- central T-cell tolerance;
- peripheral T-cell tolerance;
- B-cell tolerance;
- breaking tolerance
Summary
This chapter contains sections titled:
Introduction
Ignorance of Lymphocytes to Target Antigen
Central T-cell Tolerance
Tolerance Due to Negative T-cell Selection
Aire-driven Peripheral Antigen Expression in Medullary Thymic Epithelial Cells
Self-tolerance Associated with Positive T-cell Selection
Self-tolerance Due to Thymus-derived Regulatory T Cells: Natural Regulatory T Cells
Peripheral T-cell Tolerance
Self-tolerance Due to Regulatory T Cells Generated in the Periphery: Adaptive Regulatory T Cells
T-cell Anergy
Activation-induced Cell Death
B-cell Tolerance
Negative Selection of B Cells
B-cell Receptor Editing
B-cell Anergy
Breaking Tolerance
Concluding Remarks