Chapter 5. T-B Cell Interactions in Autoimmunity

  1. Prof. Dr. K. Michael Pollard
  1. Barbara Schraml,
  2. Stanford L. Peng

Published Online: 31 MAY 2006

DOI: 10.1002/3527607854.ch5

Book Title

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Additional Information

How to Cite

Schraml, B. and Peng, S. L. (2006) T-B Cell Interactions in Autoimmunity, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch5

Editor Information

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Author Information

  1. Department of Internal Medicine/Rheumatology and Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 25 NOV 2005

ISBN Information

Print ISBN: 9783527311415

Online ISBN: 9783527607853

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CHAPTER TOOLS

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Keywords:

  • autoantibodies;
  • autoimmunity;
  • T-B cell interactions in autoimmunity;
  • direct T-B cell interactions: receptor-mediated contacts;
  • indirect T-B cell interactions: soluble mediators;
  • cytokines;
  • nature of T-B interactions in autoimmunity

Summary

This chapter contains sections titled:

  • Introduction

  • Direct T-B Cell Interactions: Receptor-mediated Contacts

    • CD40-CD154

    • CD28 System

    • Other Costimulatory Systems

    • Cell death

  • Indirect T-B Cell Interactions: Soluble Mediators

    • Th1 versus Th2 Cytokines in Humoral Autoimmunity

    • IFN-γ

    • IL-4

    • IL-6

    • IL-10

    • Other Cytokines

  • The Nature of T-B Interactions in Autoimmunity: Ongoing Issues

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