Chapter 6. Cell Death and Autoimmunity

  1. Prof. Dr. K. Michael Pollard
  1. Carlos A. Casiano1,2,3,
  2. Fabio J. Pacheco4

Published Online: 31 MAY 2006

DOI: 10.1002/3527607854.ch6

Book Title

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Additional Information

How to Cite

Casiano, C. A. and Pacheco, F. J. (2006) Cell Death and Autoimmunity, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch6

Editor Information

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Author Information

  1. 1

    Department of Biochemistry and Microbiology, Loma Linda University School of Medicine, Mortensen Hall 132, 11085 Campus Street, Loma Linda, CA 92350, USA

  2. 2

    Center for Molecular Biology and Gene Therapy, Loma Linda University School of Medicine, Mortensen Hall 132, 11085 Campus Street, Loma Linda, CA 92350, USA

  3. 3

    Department of Medicine, Section of Rheumatology, Loma Linda University School of Medicine, Mortensen Hall 132, 11085 Campus Street, Loma Linda, CA 92350, USA

  4. 4

    Department of Morphology, Federal University of São Paulo, Rua Botucatu, 740, 04023-900 São Paulo, Brazil

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 25 NOV 2005

ISBN Information

Print ISBN: 9783527311415

Online ISBN: 9783527607853

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CHAPTER TOOLS

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Keywords:

  • autoantibodies;
  • autoimmunity;
  • cell death;
  • apoptosis;
  • necrosis;
  • impaired lymphocyte cell death and autoimmunity;
  • immunostimulatory properties of dying cells

Summary

This chapter contains sections titled:

  • Introduction

  • Apoptosis

    • Mechanistic Events in Apoptosis

  • Necrosis

    • Mechanistic Events in Necrosis

  • Impaired Lymphocyte Cell Death and Autoimmunity

  • Cell Death–associated Autoantigen Proteolysis and Autoimmunity

    • Autoantigen Proteolysis During Apoptosis

    • Autoantigen Proteolysis During Granzyme B-mediated Cytotoxicity

    • Autoantigen Cleavage During Necrosis

    • Topo I, a Model to Study Mechanisms of Cathepsin-mediated Autoantigen Cleavage During Necrosis

  • Defective Clearance of Apoptotic Cells and Autoimmunity

  • Immunostimulatory Properties of Dying Cells

  • Conclusions

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