Chapter 7. Self-antigen Modification and Autoimmunity

  1. Prof. Dr. K. Michael Pollard
  1. Stuart M. Levine1,
  2. Livia Casciola-Rosen1,2,
  3. Antony Rosen1,2,3,4

Published Online: 31 MAY 2006

DOI: 10.1002/3527607854.ch7

Book Title

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease

Additional Information

How to Cite

Levine, S. M., Casciola-Rosen, L. and Rosen, A. (2006) Self-antigen Modification and Autoimmunity, in Autoantibodies and Autoimmunity: Molecular Mechanisms in Health and Disease (ed K. M. Pollard), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527607854.ch7

Editor Information

  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 131, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA

Author Information

  1. 1

    Department of Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA

  2. 2

    Department of Dermatology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA

  3. 3

    Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA

  4. 4

    Department of Pathology, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, Baltimore, MD 21224, USA

Publication History

  1. Published Online: 31 MAY 2006
  2. Published Print: 25 NOV 2005

ISBN Information

Print ISBN: 9783527311415

Online ISBN: 9783527607853

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CHAPTER TOOLS

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Keywords:

  • autoantibodies;
  • autoimmunity;
  • self-antigen modification;
  • immunologic dominance and crypticity;
  • autoantigens;
  • proteolytic cleavage of autoantigens during apoptosis;
  • cytotoxic lymphocyte granuleinduced death pathways

Summary

This chapter contains sections titled:

  • Introduction

  • Learning to Ignore the Self: Immunologic Dominance and Crypticity

  • Proteolytic Cleavage of Autoantigens During Apoptosis

  • Cytotoxic Lymphocyte Granuleinduced Death Pathways

  • Many Autoantigens Are Specifically Cleaved by GrB, Generating Fragments Not Observed During Other Forms of Cell Death

  • Grb-induced Cleavage of Tissue-specific Autoantigens

  • Novel Conformation of Phenotype-specific Autoantigens

  • Conclusion: A Model of Antigen Selection During Cell Death

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