Chapter 12. Case Study: “Esmolol Stat” [1]

  1. Dr. János Fischer2,
  2. Prof. Dr. C. Robin Ganellin3
  1. Paul W. Erhardt

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch12

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

Erhardt, P. W. (2006) Case Study: “Esmolol Stat” [1], in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch12

Editor Information

  1. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 3

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. Center for Drug Design and Development, The University of Toledo, College of Pharmacy, Toledo, OH 43606-3390, USA

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

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CHAPTER TOOLS

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Keywords:

  • analogue-based drug discovery;
  • Esmolol Stat;
  • pharmacological target;
  • chemical target;
  • chemical synthesis;
  • pharmacology;
  • clinical profile;
  • compound libraries;
  • biological testing

Summary

This chapter contains sections titled:

  • Introduction

  • Pharmacological Target

  • Chemical Target

    • Internal Esters

    • External Esters

    • Structure–Activity Relationships

  • Chemical Synthesis

  • Pharmacology and Clinical Profile

  • Summary and Some Lessons for Today

    • Compound Libraries

    • Biological Testing

    • SAR

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