Chapter 13. Development of Organic Nitrates for Coronary Heart Disease
- Dr. János Fischer2,
- Prof. Dr. C. Robin Ganellin3
Published Online: 22 MAY 2006
DOI: 10.1002/3527608001.ch13
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Analogue-based Drug Discovery
Additional Information
How to Cite
Dézsi, L. (2006) Development of Organic Nitrates for Coronary Heart Disease, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch13
Editor Information
- 2
Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary
- 3
University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK
Publication History
- Published Online: 22 MAY 2006
- Published Print: 20 JAN 2006
ISBN Information
Print ISBN: 9783527312573
Online ISBN: 9783527608003
- Summary
- Chapter
Keywords:
- analogue-based drug discovery;
- development of organic nitrates for coronary heart disease;
- empirical observations;
- therapeutic use of classic nitrovasodilators;
- Isoamyl nitrite;
- Nitroglycerin;
- Isosorbide Dinitrate;
- Isosorbide Mononitrate;
- Nicorandil;
- cardiovascular efficacy;
- mechanism of action;
- tolerance to organic nitrates
Summary
This chapter contains sections titled:
Introduction
Empirical Observations Leading to the Therapeutic Use of Classic Nitrovasodilators
Isoamyl Nitrite: The Pioneer Drug
Nitroglycerin (Glyceryl Trinitrate): The Most Successful Analogue
Isosorbide Dinitrate: A Viable Analogue with Prolonged Action
Isosorbide Mononitrate: The Metabolite of Isosorbide Dinitrate
Nicorandil: The Potassium Channel Opener Analogue with a Broad Cardiovascular Spectrum
Cardiovascular Efficacy of Organic Nitrates
Mechanism of Action of Organic Nitrates
Tolerance to Organic Nitrates
Concluding Remarks