Chapter 14. Development of Opioid Receptor Ligands

  1. Dr. János Fischer2,
  2. Prof. Dr. C. Robin Ganellin3
  1. Christopher R. McCurdy

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch14

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

McCurdy, C. R. (2006) Development of Opioid Receptor Ligands, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch14

Editor Information

  1. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 3

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. Department of Medicinal Chemistry, The University of Mississippi, P.O. Box 1848, University, MS 38677, USA

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

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Keywords:

  • analogue-based drug discovery;
  • development of opioid receptor ligands;
  • pharmacology;
  • alkaloids;
  • morphine;
  • structure–activity relationships;
  • synthetic analogues of thebaine;
  • compounds of morphinan skeleton;
  • new agents;
  • new class of opioid ligand;
  • 4-anilidopiperidines;
  • phenylpropylamines

Summary

This chapter contains sections titled:

  • Introduction

  • Pharmacology Related to the Classic Opioid Receptors.

  • Alkaloids from the Latex of Papaver somniferum Initiate Research

  • Morphine: The Prototype Opioid Ligand

    • Initial Studies of Morphine Analogues

  • Structure–Activity Relationships of Morphine Derivatives

  • Synthetic Analogues of Thebaine Further Define Morphinan SAR

  • Compounds of the Morphinan Skeleton Produce New Agents

  • Further Reduction of the Morphinan Skeleton Produced the Benzomorphans

  • Another Simplified Version of Morphine Creates a New Class of Opioid Ligand

  • A Breakthrough in the Structural Design of Opioid Ligands

  • Discovery of the 4-Anilidopiperidines

  • Phenylpropylamines: The Most Stripped-Down Opioids Still Related to Morphine

  • The Use of Opioid Analgesics in Clinical Practice: Hope of the Future

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