Chapter 15. Stigmines

  1. Dr. János Fischer2,
  2. Prof. Dr. C. Robin Ganellin3
  1. Zeev Tashma

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch15

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

Tashma, Z. (2006) Stigmines, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch15

Editor Information

  1. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 3

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. The Hebrew University of Jerusalem, Department of Medicinal Chemistry, P.O. Box 12065, 91120 Jerusalem, Israel

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

SEARCH

CHAPTER TOOLS

Get PDF (163K)

Keywords:

  • analogue-based drug discovery;
  • stigmines;
  • physostigmine;
  • pharmacological activities;
  • chemistry and biochemistry;
  • interaction acetylcholinesterase with carbamates;
  • SAR of Eeseroline moiety;
  • carbamates as pre-exposure treatment;
  • carbamates as insecticides;
  • treatment of Alzheimer's Disease

Summary

This chapter contains sections titled:

  • Historical Background

  • Pharmacological Activities of Physostigmine

  • Chemistry and Biochemistry of Physostigmine

  • Interaction of Acetylcholinesterase with Carbamates

  • SAR of the Eseroline Moiety, and the Development of Miotine

  • The Development of Quaternary Carbamates for Myasthenia Gravis

  • Carbamates as Pre-Exposure Treatment against Organophosphate Intoxication

  • Carbamates as Insecticides

    • Structural Features

  • Carbamates in the Treatment of Alzheimer's Disease

    • Close Derivatives of Physostigmine

    • Rivastigmine

Get PDF (163K)