Chapter 16. Structural Analogues of Clozapine

  1. Dr. János Fischer3,
  2. Prof. Dr. C. Robin Ganellin4
  1. Béla Kiss1,
  2. István Bitter2

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch16

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

Kiss, B. and Bitter, I. (2006) Structural Analogues of Clozapine, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch16

Editor Information

  1. 3

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 4

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. 1

    Department of Molecular Pharmacology, Pharmacological and Drug Safety Research, Gedeon Richter Ltd, Gyömrői u. 19–21, 1103 Budapest, Hungary

  2. 2

    Semmelweis University, Clinic of Psychiatry and Psychotherapy, Balassa u. 6, 1083 Budapest, Hungary

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

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CHAPTER TOOLS

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Keywords:

  • analogue-based drug discovery;
  • structural analogues of Clozapine;
  • preclinical aspects;
  • clinical aspects

Summary

This chapter contains sections titled:

  • Introduction

  • Clozapine: The Prototype “Atypical” Antipsychotic; Some Chemical Aspects

  • Preclinical Aspects

    • Multireceptor Profile: In-Vitro, In-Vivo Similarities and Differences

    • The Availability of Data

    • Dopamine D2 versus Serotonin 5-HT2A Affinity

    • Affinity to other Receptors

    • Inverse Agonism

    • Receptor Affinity of Metabolites and Clinical Action

  • Clinical Aspects

    • Terminology

    • Indications

    • Dosage

    • Clinical Efficacy in Schizophrenia

    • Clinical Efficacy in Bipolar Disorder (Especially in Mania)

    • Adverse Events

  • Summary and Conclusions

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