Chapter 17. Quinolone Antibiotics: The Development of Moxifloxacin

  1. Dr. János Fischer2,
  2. Prof. Dr. C. Robin Ganellin3
  1. Uwe Petersen

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch17

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

Petersen, U. (2006) Quinolone Antibiotics: The Development of Moxifloxacin, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch17

Editor Information

  1. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 3

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. retired from Bayer AG, Auf dem Forst 4, 51375 Leverkusen, Germany

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

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CHAPTER TOOLS

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Keywords:

  • analogue-based drug discovery;
  • Quinolone antibiotics;
  • development of Moxifloxacin;
  • chemical evolution;
  • synthetic routes;
  • physicochemical properties;
  • microbiological and clinical properties;
  • pharmacokinetics/pharmacodynamics;
  • development of resistance;
  • safety and tolerability;
  • metabolism;
  • excretion and biodegradability of Moxifloxacin

Summary

This chapter contains sections titled:

  • Introduction

  • Aims

  • The Chemical Evolution of Moxifloxacin

  • Synthetic Routes

    • S,S–2,8-Diazabicyclo[4.3.0]nonane

    • Preparation of BAY X 8843 36 and its Analogues

    • Preparation of Moxifloxacin Hydrochloride 47

  • The Physicochemical Properties of Moxifloxacin

  • The Microbiological and Clinical Properties of Moxifloxacin

    • Mycobacterium tuberculosis

    • Skin Infections

    • Ophthalmology

    • Dental Medicine

  • Pharmacokinetics/Pharmacodynamics of Moxifloxacin

  • Development of Resistance to Moxifloxacin

  • Safety and Tolerability of Moxifloxacin

  • Metabolism, Excretion and Biodegradability of Moxifloxacin

  • Future Prospects for Quinolones

  • Summary and Conclusions

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