Chapter 19. Cisplatin and its Analogues for Cancer Chemotherapy

  1. Dr. János Fischer2,
  2. Prof. Dr. C. Robin Ganellin3
  1. Sándor Kerpel-Fronius

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch19

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

Kerpel-Fronius, S. (2006) Cisplatin and its Analogues for Cancer Chemotherapy, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch19

Editor Information

  1. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 3

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. Semmelweis University, Department of Pharmacology, Nagyvárad tér 4, 1445 Budapest, Hungary

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

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CHAPTER TOOLS

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Keywords:

  • analogue-based drug discovery;
  • cisplatin;
  • analogues;
  • cancer chemotherapy;
  • carboplatin;
  • oxaliplatin;
  • pharmacokinetics;
  • adverse effects;
  • clinical efficacy;
  • development

Summary

This chapter contains sections titled:

  • Introduction

  • Cisplatin

    • Discovery

    • Structure

    • Mechanism of Action

    • Pharmacokinetics

    • Clinical Efficacy

    • Adverse Effects

  • Carboplatin

    • Development

    • Administration and Pharmacokinetics

    • Adverse Effects

    • Clinical Efficacy

  • Oxaliplatin

    • Development

    • Cellular Resistance to Various Pt Analogues

    • Metabolism and Pharmacokinetics

    • Adverse Effects

    • Clinical Efficacy

  • Summary

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