Chapter 4. Development of Anti-Ulcer H2-Receptor Histamine Antagonists

  1. Dr. János Fischer1,
  2. Prof. Dr. C. Robin Ganellin2
  1. C. Robin Ganellin

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch4

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

Ganellin, C. R. (2006) Development of Anti-Ulcer H2-Receptor Histamine Antagonists, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch4

Editor Information

  1. 1

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 2

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

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Keywords:

  • analogue-based drug discovery;
  • development of anti-ulcer H2-receptor histamine antagonists;
  • burimamide;
  • cimetidine;
  • ranitidine;
  • tiotidine;
  • famotidine

Summary

This chapter contains sections titled:

  • Introduction

  • The Prototype Drug, Burimamide, Defined Histamine H2-Receptors

  • The Pioneer Drug, Cimetidine: A Breakthrough for Treating Peptic Ulcer Disease

  • Ranitidine: The First Successful Analogue of H2 Antagonists

  • The Discovery of Tiotidine and Famotidine

  • Other Compounds

  • The Use of H2-Receptor Histamine Antagonists as Medicines

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