Chapter 7. Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors

  1. Dr. János Fischer2,
  2. Prof. Dr. C. Robin Ganellin3
  1. Sándor Kerpel-Fronius1,
  2. János Fischer2

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch7

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

Kerpel-Fronius, S. and Fischer, J. (2006) Optimizing the Clinical Pharmacologic Properties of the HMG-CoA Reductase Inhibitors, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch7

Editor Information

  1. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 3

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. 1

    Semmelweis University, Department of Pharmacology, Nagyvárad tér 4, 1445 Budapest, Hungary

  2. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

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CHAPTER TOOLS

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Keywords:

  • analogue-based drug discovery;
  • HMG-CoA reductase inhibitors;
  • statins;
  • medicinal chemistry;
  • clinical properties;
  • pharmacologic properties;
  • clinical efficacy

Summary

This chapter contains sections titled:

  • Introduction

  • Medicinal chemistry of the Statins

  • Clinical and Pharmacologic Properties of the Statin Analogues

    • Fibrate Coadministration

  • Clinical Efficacy of the Statins

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