Chapter 8. Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers

  1. Dr. János Fischer2,
  2. Prof. Dr. C. Robin Ganellin3
  1. Csaba Farsang1,
  2. János Fischer2

Published Online: 22 MAY 2006

DOI: 10.1002/3527608001.ch8

Book Title

Analogue-based Drug Discovery

Analogue-based Drug Discovery

Additional Information

How to Cite

Farsang, C. and Fischer, J. (2006) Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers, in Analogue-based Drug Discovery (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608001.ch8

Editor Information

  1. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

  2. 3

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, UK

Author Information

  1. 1

    Semmelweis University, First Medical Clinic, Korányi S. u. 2/a, 1083 Budapest, Hungary

  2. 2

    Gedeon Richter Ltd., P.O. Box 27, H-1475 Budapest 10, Hungary

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 20 JAN 2006

ISBN Information

Print ISBN: 9783527312573

Online ISBN: 9783527608003

SEARCH

CHAPTER TOOLS

Get PDF (105K)

Keywords:

  • analogue-based drug discovery;
  • Angiotensin receptor blockers;
  • medicinal chemistry;
  • angiotensin II antagonists;
  • clinical results;
  • mechanisms of action;
  • differences among angiotensin AT1 receptor blockers;
  • structural differences;
  • AT1 receptor antagonism;
  • drug interactions;
  • efficacy in hypertension

Summary

This chapter contains sections titled:

  • Medicinal Chemistry

  • Clinical Results with Angiotensin II Antagonists

    • Mechanisms of Action

      • Other Effects of ARBs

    • Target Organ Protection

      • Left Ventricular Hypertrophy

      • Diabetic and Nondiabetic Nephropathy

      • Diabetes Prevention

      • Coronary Heart Disease (CHD)

      • Congestive Heart Failure

      • Stroke Prevention and Other CNS Effects

  • Differences Among Angiotensin AT1 Receptor Blockers

    • Structural Differences

    • AT1 Receptor Antagonism

    • Pharmacokinetics/Dosing Considerations

    • Drug Interactions/Adverse Effects

    • Efficacy in Hypertension

  • Summary

Get PDF (105K)