Chapter 23. The Search for New Antibiotics
- Prof. Dr. Dr. h. c. mult. Jörg Hacker,
- Dr. Ulrich Dobrindt
Published Online: 10 MAY 2006
DOI: 10.1002/352760801X.ch23
Copyright © 2006 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Pathogenomics: Genome Analysis of Pathogenic Microbes
Additional Information
How to Cite
Labischinski, H., Freiberg, C. and Brötz-Oesterhelt, H. (2006) The Search for New Antibiotics, in Pathogenomics: Genome Analysis of Pathogenic Microbes (eds J. Hacker and U. Dobrindt), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760801X.ch23
Editor Information
Universität Würzburg, Institut für Molekulare Infektionsbiologie, Röntgenring 11, 97070 Würzburg, Germany
Publication History
- Published Online: 10 MAY 2006
- Published Print: 9 JAN 2006
ISBN Information
Print ISBN: 9783527312658
Online ISBN: 9783527608010
- Summary
- Chapter
Keywords:
- pathogenomics;
- genomics of hosts;
- search for new antibiotics;
- need for novel antibiotics;
- genomic technologies;
- antibacterial research;
- alternative approaches in antibacterial drug discovery;
- targeting resistance mechanism;
- extremely narrow-spectrum drugs;
- phage therapies;
- reducing virulence
Summary
This chapter contains sections titled:
The Need for Novel Antibiotics
Where Will the New Antibiotics Come From?
The Past
The Present
Future Directions
Contributions of Genomic Technologies to Antibacterial Research
Target Identification and Validation
Target Prioritization
Genetic Tools for Drug Screening and Mode-of-Action Determination
Genome-Wide Expression Profiling for Mode-of-Action Characterization
Outlook for Genomic Technologies for Antibiotic Drug Discovery
Alternative Approaches in Antibacterial Drug Discovery
Targeting the Resistance Mechanism
Extremely Narrow-Spectrum Drugs
Phage Therapies and other Bacteriolytic Approaches
Strategies for Reducing Virulence and/or Influencing Pathogenesis