Chapter 11. The Role of CREB and CBP in Brain Function

  1. Prof. Dr. Gerald Thiel
  1. Angel Barco1 and
  2. Eric R. Kandel2

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch11

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Barco, A. and Kandel, E. R. (2005) The Role of CREB and CBP in Brain Function, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch11

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. 1

    Instituto de Neurociencias de Alicante (UMH-CSIC), Campus de Sant Joan, Apt. 18, Sant Joan d'Alicant 03550, Spain

  2. 2

    Howard Hughes Medical Institute and the Kavli Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, 1051 Riverside Drive, New York, New York 10032, USA

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • brain function;
  • role of CREB;
  • role of CBP;
  • CREB binding protein;
  • CREB activation pathway;
  • dysregulation of CREB function;
  • disease in nervous system;
  • regulation of cellular responses;
  • regulation of systemic responses

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • The CREB Family of Transcription Factors

    • CREB Family Members and Close Friends

    • Structural Features of the CREB Family of Transcription Factors

    • Gene Structure and the Regulation of Expression of CREB Family Members

  • The CREB Binding Protein

    • Structure and Multifunction

  • The CREB Activation Pathway

    • Post-Translational Regulation of CREB Activity

    • Regulation of CBP Function

    • Other Modulators of the CREB Pathway

    • CRE-Binding Activity and CREB Downstream Genes

  • Functions of the CREB Activation Pathway in the Nervous System

    • Regulation of Cellular Responses by the CREB Pathway

      • CREB is Important for Neuronal Survival and Neuroprotection

      • CREB is Required for Axonal Outgrowth and Regeneration

      • CREB has a Role in Neurogenesis and Neuronal Differentiation

      • CBP, Epigenetics and Long-Term Changes in Neuronal Function

    • Regulation of Systemic Responses by the CREB Pathway

      • CREB and Memory

      • CREB and Circadian Rhythms

      • CREB Function and Development

  • Dysregulation of CREB Function and Disease in the Nervous System

    • CREB and Addiction

    • Mental Retardation

    • CREB and Age-Related Memory Impairment

    • CREB and Neurodegenerative Diseases

      • Huntington Disease

      • Alzheimer's Disease

    • CREB and Mental Disorders: Depression and other Disorders of Mood

  • Conclusions

  • Abbreviations