Chapter 13. The Role of c-Jun in Brain Function

  1. Prof. Dr. Gerald Thiel
  1. Gennadij Raivich1 and
  2. Axel Behrens2

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch13

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Raivich, G. and Behrens, A. (2005) The Role of c-Jun in Brain Function, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch13

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. 1

    Perinatal Brain Repair Group, Department of Obstetrics and Gynaecology, Department of Anatomy, University College London, Gower Street Campus, 86–96 Chenies Mews, London WC1E 6HX, UK

  2. 2

    Mammalian Genetics Laboratory, Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, 44, Lincoln's Inn Fields, London WC2A 3PX, UK

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • brain function;
  • role of C-Jun in brain function;
  • C-Jun phosphorylation;
  • upstream signaling;
  • novelty;
  • learning;
  • memory;
  • addiction;
  • seizures;
  • excitotoxicity;
  • ischemia;
  • stroke;
  • brain trauma;
  • axotomy

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • C-Jun Phosphorylation and Upstream Signaling

    • Mitogen-Activated/Stress-Activated Protein Kinase (MAPK/SAPK) Level

    • MAP Kinase Kinase (MEK/MKK) and MAP Kinase Kinase Kinase (MEKK) Level

    • Scaffolding Proteins

      • Multimodal Effects of Deletion

  • Development

  • Novelty, Learning and Memory, and Addiction

    • Novelty and Pain

    • Learning

    • Addiction

  • Seizures and Excitotoxicity

  • Ischemia, Stroke, and Brain Trauma

    • Biochemical Regulation

    • Role of Jun

    • Functional Role of JNK Cascade

    • Direct Evidence

  • Axotomy

    • Regulation

    • Functional Role: Only Partial Overlap with Jun and JNK

  • Conclusions

  • Abbreviations