Chapter 14. Expression, Function, and Regulation of Transcription Factor MEF2 in Neurons

  1. Prof. Dr. Gerald Thiel
  1. Zixu Mao and
  2. Xuemin Wang

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch14

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Mao, Z. and Wang, X. (2005) Expression, Function, and Regulation of Transcription Factor MEF2 in Neurons, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch14

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. Department of Pharmacology, Center for Neurodegenerative Disease, Emory University, 615 Michael Street, Atlanta, Georgia 30329, USA

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • brain function;
  • MEF2 family of transcription factors;
  • expression of Mef2 in neurons;
  • function of Mef2 in neurons;
  • regulation of MEF2 in neurons

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • The MEF2 Family of Transcription Factors

    • MEF2 Genes and Transcripts

    • Structure of MEF2 Proteins

    • Specific Interaction Between MEF2 and DNA

  • Expression of Mef2 in Neurons

    • Expression of mef2 Transcripts in the Central Nervous System

    • Expression of MEF2 Proteins in Neurons

  • Function of Mef2 in Neurons

    • The Role of MEF2 in Neuronal Differentiation

    • The Role of MEF2 in Neuronal Survival

    • Regulatory Targets of MEF2 in Neurons

  • Regulation of MEF2 in Neurons

    • Regulation of MEF2 Transactivation Potential

    • Regulation of MEF2 DNA Binding

    • Regulation of MEF2 Stability

    • Regulation of MEF2 Subcellular Localization

    • Regulation of MEF2 by Alternative Splicing

    • Regulation of MEF2 by Interaction with Co-Regulators

    • Regulation of MEF2 by Calcium Signaling

  • Future Studies

  • Acknowledgments

  • Abbreviations