Chapter 15. RORα: An Orphan that Staggers the Mind

  1. Prof. Dr. Gerald Thiel
  1. Peter M. Gent1 and
  2. Bruce A. Hamilton2

Published Online: 22 MAY 2006

DOI: 10.1002/3527608036.ch15

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

How to Cite

Gent, P. M. and Hamilton, B. A. (2005) RORα: An Orphan that Staggers the Mind, in Transcription Factors in the Nervous System: Development, Brain Function, and Diseases (ed G. Thiel), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527608036.ch15

Editor Information

  1. Department of Medical Biochemistry and Molecular Biology, University of Saarland Medical Center, Building 44, 66421 Homburg, Germany

Author Information

  1. 1

    Biomedical Sciences Graduate Program, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0644, USA

  2. 2

    Department of Medicine, Division of Genetics, University of California, San Diego School of Medicine, 9500 Gilman Drive, La Jolla, California 92093-0644, USA

Publication History

  1. Published Online: 22 MAY 2006
  2. Published Print: 16 DEC 2005

ISBN Information

Print ISBN: 9783527312856

Online ISBN: 9783527608034

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Keywords:

  • transcription factors;
  • brain function;
  • RORα;
  • biochemical properties of RORα;
  • isoforms;
  • activation of RORα expression;
  • regulation of RORα expression;
  • role of RORα in developing cerebellum;
  • roles of RORα in other tissues;
  • in-vivo identification of RORα targets;
  • implication of RORα in SCA1 disorder

Summary

This chapter contains sections titled:

  • Abstract

  • Introduction

  • Identification and Biochemical Properties of RORα

    • Identification

    • Isoforms

    • RORα Binding and Response Elements

    • Crosstalk Between Factors

    • Ligands or Cofactors?

    • Co-activators

    • Co-repressors

    • Activation and Regulation of RORα Expression

    • RORα Expression in the Nervous System

  • Role of RORα in the Developing Cerebellum

  • Roles of RORα in Other Tissues

    • Suprachiasmatic Nuclei

    • Peripheral Tissues

  • In-Vivo Identification of RORα Targets

    • Genetic Program Controlled by RORα in the Cerebellum

    • Direct or Indirect Targets?

    • Developmental Signaling Genes

    • Calcium Signaling and Synaptic Function Genes

  • Implication of RORα in SCA1 Disorder

  • Summary

  • Abbreviations